Ann Surg Oncol (2018) 25:2279–2287 https://doi.org/10.1245/s10434-018-6549-8 OR IG INA L A R TIC L E – BREA S T O NC OLOG Y Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander–Implant Breast Reconstruction After Postmastectomy Radiotherapy 1 2 1 1 Il-Kug Kim, MD, PhD , Seong Oh Park, MD , Hak Chang, MD, PhD , and Ung Sik Jin, MD, PhD Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Plastic and Reconstructive Surgery, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea ABSTRACT capsules. With the exception of EndoMT, all others were Background. Capsular contracture is one of the most increased in irradiated submuscular capsules compared common complications of expander–implant breast recon- with nonirradiated submuscular capsule, while none sig- struction. Recently, clinical reports have shown that use of niﬁcantly differed between nonirradiated and irradiated an acellular dermal matrix (ADM) to cover breast implants ADM capsules. decreases incidence of capsular contracture, but the Conclusions. Use of ADM reduced myoﬁbroblasts, vas- underlying mechanism is unclear. Here, we examine how cularity, ﬁbroblasts, and EndoMT in capsule tissues. ADM reduces capsular formation in expander–implant Moreover, ADM use decreased macrophages, a
Annals of Surgical Oncology – Springer Journals
Published: May 31, 2018
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