Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander–Implant Breast Reconstruction After Postmastectomy Radiotherapy

Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander–Implant Breast... Ann Surg Oncol https://doi.org/10.1245/s10434-018-6549-8 OR IG INA L A R TIC L E – BREA S T O NC OLOG Y Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander–Implant Breast Reconstruction After Postmastectomy Radiotherapy 1 2 1 1 Il-Kug Kim, MD, PhD , Seong Oh Park, MD , Hak Chang, MD, PhD , and Ung Sik Jin, MD, PhD Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Plastic and Reconstructive Surgery, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea ABSTRACT capsules. With the exception of EndoMT, all others were Background. Capsular contracture is one of the most increased in irradiated submuscular capsules compared common complications of expander–implant breast recon- with nonirradiated submuscular capsule, while none sig- struction. Recently, clinical reports have shown that use of nificantly differed between nonirradiated and irradiated an acellular dermal matrix (ADM) to cover breast implants ADM capsules. decreases incidence of capsular contracture, but the Conclusions. Use of ADM reduced myofibroblasts, vas- underlying mechanism is unclear. Here, we examine how cularity, fibroblasts, and EndoMT in capsule tissues. ADM reduces capsular formation in expander–implant Moreover, ADM use decreased macrophages, a key regu- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Surgical Oncology Springer Journals

Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander–Implant Breast Reconstruction After Postmastectomy Radiotherapy

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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Society of Surgical Oncology
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery
ISSN
1068-9265
eISSN
1534-4681
D.O.I.
10.1245/s10434-018-6549-8
Publisher site
See Article on Publisher Site

Abstract

Ann Surg Oncol https://doi.org/10.1245/s10434-018-6549-8 OR IG INA L A R TIC L E – BREA S T O NC OLOG Y Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander–Implant Breast Reconstruction After Postmastectomy Radiotherapy 1 2 1 1 Il-Kug Kim, MD, PhD , Seong Oh Park, MD , Hak Chang, MD, PhD , and Ung Sik Jin, MD, PhD Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Plastic and Reconstructive Surgery, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea ABSTRACT capsules. With the exception of EndoMT, all others were Background. Capsular contracture is one of the most increased in irradiated submuscular capsules compared common complications of expander–implant breast recon- with nonirradiated submuscular capsule, while none sig- struction. Recently, clinical reports have shown that use of nificantly differed between nonirradiated and irradiated an acellular dermal matrix (ADM) to cover breast implants ADM capsules. decreases incidence of capsular contracture, but the Conclusions. Use of ADM reduced myofibroblasts, vas- underlying mechanism is unclear. Here, we examine how cularity, fibroblasts, and EndoMT in capsule tissues. ADM reduces capsular formation in expander–implant Moreover, ADM use decreased macrophages, a key regu-

Journal

Annals of Surgical OncologySpringer Journals

Published: May 31, 2018

References

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