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(2012)
Controlling complexity: the clinical relevance of mouse complex geneticsEur J Hum Genet, 21
(2015)
INFRAFRONTIER—providing mutant mouse resources as research tools for the international scientific communityNucleic Acids Res, 43
(2007)
EUCOMM—the European Conditional Mouse Mutagenesis ProgramBrief Funct Genom Proteom, 6
(2003)
Knockouts model the 100 best-selling drugs—will they model the next 100?Nat Rev Drug Discov, 2
(2007)
The mouse ascending: perspectives for human disease modelsNat Cell Biol, 9
(2011)
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous miceJ Gerontol A, 66
(2011)
Mouse phenotypingMethods, 53
(2005)
Introducing the German Mouse Clinic: Open access platform for standardized phenotypingNat Methods, 2
(2015)
The economics of reproducibility in preclinical researchPLoS Biol, 13
(2010)
Validating animal models for preclinical research: a scientific and ethical discussionATLA, 38
(2014)
Contemporary techniques for freezing mouse spermatozoaCurr Protoc Mouse Biol, 4
(2014)
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping dataNucleic Acids Res, 42
(2009)
Systemic first-line phenotypingMethods Mol Biol, 530
(2015)
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic miceDiabetes, 64
(2009)
Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modellingNat Rev Genet, 10
(2012)
Innovations in phenotyping of mouse models in the German Mouse ClinicMamm Genome, 23
(2007)
EMMA—the European mouse mutant archiveBrief Funct Genom Proteom, 6
(2015)
Rodent models for human diseasesEur J Pharmacol, 759
(2007)
A mouse for all reasonsCell, 128
(2015)
Effects of vendor and genetic background on the composition of the fecal microbiota of inbred micePLoS One, 10
(2015)
The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resourcesMamm Genome, 26
(2015)
Reproducibility: use biobanks or lose themNature, 522
(2016)
Using the mouse to model human disease: increasing validity and reproducibilityDis Model Mech, 9
(2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous miceNature, 460
(2014)
Transporting mouse embryos and germplasm as frozen or unfrozen materialsCurr Protoc Mouse Biol, 4
(2013)
Rapamycin extends murine lifespan but has limited effects on agingJ Clin Invest, 123
(2014)
Preclinical research: make mouse studies workNature, 507
(2010)
EuroPhenome: a repository for high-throughput mouse phenotyping dataNucleic Acids Res, 38
(2012)
The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotypingMamm Genome, 23
(2015)
Transparency in research involving animals: the basel declaration and the new principles for reporting research in BJP manuscriptsBr J Pharmacol, 172
(2006)
The mighty mouse: genetically engineered mouse models in cancer drug developmentNat Rev Drug Discov, 5
(2016)
Sustaining large-scale infrastructure to promote pre-competitive biomedical research: lesson from mouse genomicsNew Biotechnol, 2
Ageing research and more generally the study of the functional basis of human diseases profit enormously from the large-scale approaches and resources in mouse functional genomics: systematic targeted mutation of the mouse genome, systemic phenotyping in mouse clinics, and the archiving and distribution of the mouse resources in public repositories. INFRAFRONTIER, the European research infrastructure for the development, systemic phenotyping, archiving and distribution of mammalian models, offers access to sustainable mouse resources for biomedical research. INFRAFRONTIER promotes the global sharing of high-quality resources and data and thus contributes to data reproducibility and animal welfare. INFRAFRONTIER puts great effort into international standardisation and quality control and into technology development to improve and expand experimental protocols, reduce the use of animals in research and increase the reproducibility of results. In concert with the research community and the International Mouse Phenotyping Consortium (IMPC), INFRAFRONTIER is currently developing new pilot platforms and services for the research on ageing and age-related diseases.
Mammalian Genome – Springer Journals
Published: Jun 4, 2016
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