Information-Theoretic Approaches to Understanding Stem Cell Variability

Information-Theoretic Approaches to Understanding Stem Cell Variability Curr Stem Cell Rep (2017) 3:225–231 DOI 10.1007/s40778-017-0093-5 MATHEMATICAL MODELS OF STEM CELL BEHAVIOR (M KOHANDEL, SECTION EDITOR) Information-Theoretic Approaches to Understanding Stem Cell Variability 1,2 1,2,3 Rosanna C.G. Smith & Ben D. MacArthur Published online: 13 July 2017 Springer International Publishing AG 2017 Abstract Introduction Purpose of Review The purpose of this study is to outline how ideas from information theory may be used to analyze single- Stem cells are characterized by their ability to self-renew and cell data and better understand stem cell behavior. differentiate along multiple distinct lineages. Due to these re- Recent Findings Recent technological breakthroughs in markable properties, there is much hope for stem cell-based single-cell profiling have made it possible to interrogate therapies in regenerative medicine. However, the develop- cell–cell variability in a multitude of contexts, including the ment of such therapies will require a thorough understanding role it plays in stem cell dynamics. Here we review how mea- of the molecular mechanisms by which stem cells balance sures from information theory are being used to extract bio- self-renewal and differentiation. Since stem cells are often rare logical meaning from the complex, high-dimensional, and (as in the adult) or exist only transiently (as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Stem Cell Reports Springer Journals

Information-Theoretic Approaches to Understanding Stem Cell Variability

Loading next page...
 
/lp/springer_journal/information-theoretic-approaches-to-understanding-stem-cell-jaJyLxa6tl
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Life Sciences; Cell Biology; Stem Cells
eISSN
2198-7866
D.O.I.
10.1007/s40778-017-0093-5
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial