Mamm Genome (2015) 26:521–539 DOI 10.1007/s00335-015-9581-z Informatics resources for the Collaborative Cross and related mouse populations 1 2 Andrew P. Morgan Catherine E. Welsh Received: 16 March 2015 / Accepted: 23 June 2015 / Published online: 2 July 2015 Springer Science+Business Media New York 2015 Introduction remains mostly unexplored—has limited the number of extant lines to *150 at time of writing. Nonetheless, the CC The Collaborative Cross (CC) and the complementary has begun to fulﬁll its promise as a source of extreme Diversity Outbred (DO) population were conceived as a phenotypic variability and associated candidate loci (Iraqi platform for the next generation of studies of the genetic et al. 2014). Within just the past year, CC lines have been basis for complex traits in mouse (Churchill et al. 2004). shown to be highly variable for traits related to both normal The CC promised to combine the strengths of existing physiology and disease, including gene expression in panels of recombinant inbred (RI) lines [e.g., BXD (Taylor healthy liver (Aylor et al. 2011; Weiser et al. 2014), allergic et al. 1973), LXS (Williams et al. 2004)] and inbred strains airway inﬂammation (Kelada et al. 2014), lymphocyte (Ghazalpour et al. 2012)—phenotypic variation,
Mammalian Genome – Springer Journals
Published: Jul 2, 2015
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