Informatics resources for the Collaborative Cross and related mouse populations

Informatics resources for the Collaborative Cross and related mouse populations Mamm Genome (2015) 26:521–539 DOI 10.1007/s00335-015-9581-z Informatics resources for the Collaborative Cross and related mouse populations 1 2 Andrew P. Morgan Catherine E. Welsh Received: 16 March 2015 / Accepted: 23 June 2015 / Published online: 2 July 2015 Springer Science+Business Media New York 2015 Introduction remains mostly unexplored—has limited the number of extant lines to *150 at time of writing. Nonetheless, the CC The Collaborative Cross (CC) and the complementary has begun to fulfill its promise as a source of extreme Diversity Outbred (DO) population were conceived as a phenotypic variability and associated candidate loci (Iraqi platform for the next generation of studies of the genetic et al. 2014). Within just the past year, CC lines have been basis for complex traits in mouse (Churchill et al. 2004). shown to be highly variable for traits related to both normal The CC promised to combine the strengths of existing physiology and disease, including gene expression in panels of recombinant inbred (RI) lines [e.g., BXD (Taylor healthy liver (Aylor et al. 2011; Weiser et al. 2014), allergic et al. 1973), LXS (Williams et al. 2004)] and inbred strains airway inflammation (Kelada et al. 2014), lymphocyte (Ghazalpour et al. 2012)—phenotypic variation, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Informatics resources for the Collaborative Cross and related mouse populations

Loading next page...
 
/lp/springer_journal/informatics-resources-for-the-collaborative-cross-and-related-mouse-BV00lr5Bob
Publisher
Springer US
Copyright
Copyright © 2015 by Springer Science+Business Media New York
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-015-9581-z
Publisher site
See Article on Publisher Site

Abstract

Mamm Genome (2015) 26:521–539 DOI 10.1007/s00335-015-9581-z Informatics resources for the Collaborative Cross and related mouse populations 1 2 Andrew P. Morgan Catherine E. Welsh Received: 16 March 2015 / Accepted: 23 June 2015 / Published online: 2 July 2015 Springer Science+Business Media New York 2015 Introduction remains mostly unexplored—has limited the number of extant lines to *150 at time of writing. Nonetheless, the CC The Collaborative Cross (CC) and the complementary has begun to fulfill its promise as a source of extreme Diversity Outbred (DO) population were conceived as a phenotypic variability and associated candidate loci (Iraqi platform for the next generation of studies of the genetic et al. 2014). Within just the past year, CC lines have been basis for complex traits in mouse (Churchill et al. 2004). shown to be highly variable for traits related to both normal The CC promised to combine the strengths of existing physiology and disease, including gene expression in panels of recombinant inbred (RI) lines [e.g., BXD (Taylor healthy liver (Aylor et al. 2011; Weiser et al. 2014), allergic et al. 1973), LXS (Williams et al. 2004)] and inbred strains airway inflammation (Kelada et al. 2014), lymphocyte (Ghazalpour et al. 2012)—phenotypic variation,

Journal

Mammalian GenomeSpringer Journals

Published: Jul 2, 2015

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off