Reactions 1680, p179 - 2 Dec 2017 Influenza virus vaccine live/ paracetamol Anaphylaxis, syncope and Stevens‐Johnson syndrome: 3 case reports In a study to evaluate the safety of live attenuated influenza vaccine, 3 patients were described [sexes not stated; not all ages stated], of whom one patient patient developed Stevens‐Johnson syndrome following treatment with paracetamol [acetaminophen], one patient developed syncope and a 3-year-old patient developed anaphylaxis following treatment with influenza virus vaccine live [routes and dosages not stated; not all times to reaction onsets and outcomes stated]. Case 1: One patient received paracetamol, concurrently with influenza virus vaccine live. However, following paracetamol administration, the patient developed Stevens‐Johnson syndrome that was considered to be caused by paracetamol. Case 2: One patient received treatment with influenza virus vaccine live. However, within few minutes of the influenza- virus vaccine live administration, the patient developed treatment-related syncope. Case 3: A 3‐ year‐old patient received treatment with influenza virus vaccine live. However, after 2 hours of the vaccination, the patient developed anaphylaxis with symptoms of wheezing, lip swelling and hives, which were considered to be treatment-related. Though a history of egg allergy was noted, the patient had received injectable influenza vaccine in the past without an allergic reaction. Eventually, the patient’s anaphylaxis had completely recovered. Author comment: "One case of Stevens‐Johnson syndrome occurred in the risk period following [influenza- virus vaccine live]: acetaminophen was considered the cause, although the subject had also been exposed to LAIV preceding development of Stevens‐Johnson syndrome." "One confirmed syncope case occurred in an individual who received LAIV and no other vaccines". "One case of anaphylaxis occurred in the risk window. . .2 hours after receiving LAIV." Daley MF, et al. The safety of live attenuated influenza vaccine in children and adolescents 2 through 17 years of age: A Vaccine Safety Datalink study. Pharmacoepidemiology and Drug Safety : 17 Nov 2017. Available from: URL: http://doi.org/10.1002/pds.4349 - USA 803284286 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
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