Influenza-virus-vaccine Reactions 1680, p180 - 2 Dec 2017 Acute disseminated encephalomyelitis: case report A 55-year-old woman developed acute disseminated encephalomyelitis (ADEM) following the administration of seasonal influenza virus vaccine. The woman, who was wheel chair bound, had a history of traumatic cervical spinal cord injury. She presented with fever and confusion. Subsequently, she was hospitalised. A month prior to the presentation, she was administered a seasonal influenza virus vaccine [route and dosage not stated]. Her neurological examination showed Babinski sign with quadriplegia and hyper-reflexia of limb tendons. CSF analysis resulted in pleocytosis with glucose content of 88 g/dL and protein content of 108 g/dL. Thereafter, she underwent MRI scan of the brain, which showed the images of ADEM. The woman was started on steroid pulse therapy, and significant improvement was noted after five days. She recovered completely in the following two weeks. Author comment: "This case elucidates the occurrence risk of ADEM in patients with altered mental status after seasonal influenza vaccination, emphasizing the importance of recognizing recent vaccination exposures. . .The vaccines against seasonal influenza are the most frequently reported to be associated with ADEM." Choi K-H, et al. Altered mental status after seasonal influenza vaccination. Journal of Clinical Neuroscience 43: 118, Sep 2017. Available from: URL: http:// - South Korea 803285115 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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