Reactions 1680, p180 - 2 Dec 2017
Acute disseminated encephalomyelitis: case report
A 55-year-old woman developed acute disseminated
encephalomyelitis (ADEM) following the administration of
seasonal influenza virus vaccine.
The woman, who was wheel chair bound, had a history of
traumatic cervical spinal cord injury. She presented with fever
and confusion. Subsequently, she was hospitalised. A month
prior to the presentation, she was administered a seasonal
influenza virus vaccine [route and dosage not stated]. Her
neurological examination showed Babinski sign with
quadriplegia and hyper-reflexia of limb tendons. CSF analysis
resulted in pleocytosis with glucose content of 88 g/dL and
protein content of 108 g/dL. Thereafter, she underwent MRI
scan of the brain, which showed the images of ADEM.
The woman was started on steroid pulse therapy, and
significant improvement was noted after five days. She
recovered completely in the following two weeks.
Author comment: "This case elucidates the occurrence
risk of ADEM in patients with altered mental status after
seasonal influenza vaccination, emphasizing the importance
of recognizing recent vaccination exposures. . .The vaccines
against seasonal influenza are the most frequently reported to
be associated with ADEM."
Choi K-H, et al. Altered mental status after seasonal influenza vaccination. Journal
of Clinical Neuroscience 43: 118, Sep 2017. Available from: URL: http://
doi.org/10.1016/j.jocn.2017.03.020 - South Korea
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved