Nanosized mesoporous iron–carboxylate [MIL-100(Fe)]-encapsulated Keggin phosphotungstic acid H3PW12O40 (PW) was fabricated via an environmentally friendly hydrothermal synthesis method and characterized by Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy, field-emission scanning electron microscopy, particle size analysis, and powder X-ray diffraction analysis. The metal content was analyzed by energy-dispersive X-ray spectroscopy. PW@MIL-100(Fe) was then studied as a drug delivery system, exhibiting the ability to entrap epirubicin (EPI) as a model drug. The drug loading efficiency, drug content, and drug release behavior of PW@MIL-100(Fe), MIL-100(Fe), and PW@HKUST-1 [where HKUST-1 is Cu3(BTC)2 with BTC = benzene-1,3,5-tricarboxylic acid] were also studied. The results indicate that PW@MIL-100(Fe) possessed high adsorption capacity (28 wt%) and loading efficiency (91.6 %) for epirubicin. Drug release from PW@MIL-100(Fe) at different pH values (5, 5.8, 6.5, and 7.4) and temperatures and with an alternative magnetic field was investigated, and the stability of the nanocarrier after EPI release was studied by Fourier-transform infrared spectroscopy and field-emission scanning electron microscopy. Cellular toxicity was also investigated. The results show that this is a good candidate as a future drug nanocarrier.
Research on Chemical Intermediates – Springer Journals
Published: Aug 10, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera