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Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Assisted Reproduction and Genetics Springer Journals

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Gynecology; Reproductive Medicine; Human Genetics
ISSN
1058-0468
eISSN
1573-7330
DOI
10.1007/s10815-018-1143-3
pmid
29497954
Publisher site
See Article on Publisher Site

Abstract

An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment.

Journal

Journal of Assisted Reproduction and Genetics – Springer Journals

Published: Mar 2, 2018

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  • Performance of patients with a “frozen pelvis” in an in vitro fertilization program
    Molloy, D; Martin, M; Speirs, A; Lopata, A; Clarke, G; McBain, J
  • The relation between immunoglobulin G antibodies to Chlamydia trachomatis and poor ovarian response to gonadotropin stimulation before in vitro fertilization
    Keay, SD; Barlow, R; Eley, A; Masson, GM; Anthony, FW; Jenkins, JM
  • ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria
    Ferraretti, AP; Marca, A; Fauser, BC; Tarlatzis, B; Nargund, G; Gianaroli, L
  • Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging
    Beckers, NG; Macklon, NS; Eijkemans, MJ; Fauser, BC
  • A low number of retrieved oocytes at in vitro fertilization treatment is predictive of early menopause
    Boer, EJ; Tonkelaar, I; Velde, ER; Burger, CW; Klip, H; Leeuwen, FE
  • Poor response to ovulation induction is a stronger predictor of early menopause than elevated basal FSH: a life table analysis
    Lawson, R; El-Toukhy, T; Kassab, A; Taylor, A; Braude, P; Parsons, J
  • A retrospective evaluation of prognosis and cost-effectiveness of IVF in poor responders according to the Bologna criteria
    Busnelli, A; Papaleo, E; Prato, D; Vecchia, I; Iachini, E; Paffoni, A
  • Does poor ovarian response to gonadotrophins predict early menopause? A retrospective cohort study with minimum of 10-year follow-up
    Szmidt, NA; Bhattacharya, S; Maheshwari, A
  • Regulation of ovarian follicular development in primates: facts and hypotheses
    Gougeon, A
  • Ovarian follicular cells have innate immune capabilities that modulate their endocrine function
    Herath, S; Williams, EJ; Lilly, ST; Gilbert, RO; Dobson, H; Bryant, CE
  • Lipopolysaccharide initiates inflammation in bovine granulosa cells via the TLR4 pathway and perturbs oocyte meiotic progression in vitro
    Bromfield, JJ; Sheldon, IM
  • Lipopolysaccharide reduces the primordial follicle pool in the bovine ovarian cortex ex vivo and in the murine ovary in vivo
    Bromfield, JJ; Sheldon, IM
  • Obesity and assisted reproductive technology outcomes
    Bellver, J; Busso, C; Pellicer, A; Remohí, J; Simón, C
  • Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates
    Luke, B; Brown, MB; Stern, JE; Missmer, SA; Fujimoto, VY; Leach, R
  • Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles
    Marquard, KL; Stephens, SM; Jungheim, ES; Ratts, VS; Odem, RR; Lanzendorf, S
  • The association between severe obesity and characteristics of failed fertilized oocytes
    Machtinger, R; Combelles, CM; Missmer, SA; Correia, KF; Fox, JH; Racowsky, C
  • The impact of obesity on egg quality
    Purcell, SH; Moley, KH
  • The adverse effects of obesity on conception and implantation
    Brewer, CJ; Balen, AH
  • The insulin-related ovarian regulatory system in health and disease
    Poretsky, L; Cataldo, NA; Rosenwaks, Z; Giudice, LC
  • The decrease in luteinizing hormone secretion in response to weight reduction is inversely related to the severity of insulin resistance in overweight women
    Bützow, TL; Lehtovirta, M; Siegberg, R; Hovatta, O; Koistinen, R; Seppäla, M
  • Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients
    Phy, JL; Conover, CA; Abbott, DH; Zschunke, MA; Walker, DL; Session, DR
  • Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women
    Robker, RL; Akison, LK; Bennett, BD; Thrupp, PN; Chura, LR; Russell, DL
  • Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice
    Wang, Q; Frolova, AI; Purcell, S; Adastra, K; Schoeller, E; Chi, MM
  • Decreased oocyte-granulosa cell gap junction communication and connexin expression in a type 1 diabetic mouse model
    Ratchford, AM; Esguerra, CR; Moley, KH
  • Physiological changes in oocyte-cumulus cell complexes from diabetic mice that potentially influence meiotic regulation
    Colton, SA; Humpherson, PG; Leese, HJ; Downs, SM
  • Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model
    Boots, CE; Boudoures, A; Zhang, W; Drury, A; Moley, KH
  • Implications of polycystic ovary syndrome on oocyte development
    Dumesic, DA; Abbott, DH
  • Follicular dynamics in the polycystic ovary syndrome
    Franks, S; Mason, H; Willis, D
  • Follicle luteinization in hyperandrogenic follicles of polycystic ovary syndrome patients undergoing gonadotropin therapy for in vitro fertilization
    Foong, SC; Abbott, DH; Zschunke, MA; Lesnick, TG; Phy, JL; Dumesic, DA
  • mRNA expression pattern of insulin-like growth factor components of granulosa cells and cumulus cells in women with and without polycystic ovary syndrome according to oocyte maturity
    Kwon, H; Choi, DH; Bae, JH; Kim, JH; Kim, YS
  • The transcriptome of corona radiata cells from individual MІІ oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women
    Wissing, ML; Sonne, SB; Westergaard, D; Nguyen, K; Belling, K; Høst, T
  • Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8
    Huang, X; Liu, C; Hao, C; Tang, Q; Liu, R; Lin, S
  • Altered microRNAs expression profiling in cumulus cells from patients with polycystic ovary syndrome
    Liu, S; Zhang, X; Shi, C; Lin, J; Chen, G; Wu, B
  • Epigenetic modification of long interspersed elements-1 in cumulus cells of mature and immature oocytes from patients with polycystic ovary syndrome
    Pruksananonda, K; Wasinarom, A; Sereepapong, W; Sirayapiwat, P; Rattanatanyong, P; Mutirangura, A
  • Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan
    Teede, H; Deeks, A; Moran, L
  • Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women
    Cano, F; García-Velasco, JA; Millet, A; Remohí, J; Simón, C; Pellicer, A
  • Effects of hyperandrogenism on metabolic abnormalities in patients with polycystic ovary syndrome: a meta-analysis
    Yang, R; Yang, S; Li, R; Liu, P; Qiao, J; Zhang, Y
  • Overexpression of ribosomal RNA in cumulus cells of patients with polycystic ovary syndrome
    Polzikov, M; Yakovenko, S; Voznesenskaya, J; Troshina, M; Zatsepina, O