Pharm Res (2018) 35: 134 https://doi.org/10.1007/s11095-018-2419-0 RESEARCH PAPER Influence of Fatty Acid Modif ication on Uptake of Lovastatin-Loaded Reconstituted High Density Lipoprotein by Foam Cells 1 1,2 1 1 1 1 Yun Yang & Ji Wang & Hongliang He & Wenli Zhang & Yuansheng Zhang & Jianping Liu Received: 9 January 2018 /Accepted: 23 April 2018 /Published online: 7 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT the opposite was true for SA modification. The AA-modified Purpose Spherical reconstituted high density lipoprotein rHDL exhibited a higher uptake of foam cells expressing (rHDL) can target atherosclerotic lesions by the very low den- CETP than the non-modified one, while the SA-modified sity lipoprotein (VLDL) receptor, which is seldom expressed in one showed the lowest cellular uptake among the three liver. By promoting this pathway, the targeting efficiency was rHDLs. hyphothesized to be improved due to avoiding undesired up- Conclusions Increased unsaturation level can facilitate lipid- take in liver mediated by the scavenger receptor class B type I interchange process where the cargo in rHDL core may trans- (SR-BI). In this study, how fatty acid modification in spherical fer to VLDL more easily, and then promote the
Pharmaceutical Research – Springer Journals
Published: May 7, 2018
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