Influence of different delivery modes on the clinical characteristics
of Chlamydia trachomatis pneumonia
Received: 5 January 2018 /Revised: 28 March 2018 /Accepted: 5 April 2018
Springer-Verlag GmbH Germany, part of Springer Nature 2018
We analyzed the effects of delivery methods on Chlamydia trachomatis pneumonia in infants. Three hundred forty-four children
hospitalized with Chlamydia trachomatis pneumonia were enrolled. They were divided into the vaginal delivery group and the
cesarean delivery group. We compared and analyzed their age of onset, peripheral blood white blood cell count, liver enzymes,
chlamydia trachomatis titers, and chest radiograph scores. Seventy-eight (22.7%) were delivered by a cesarean, and 266 (77.3%)
were delivered vaginally. There were no statistically significant differences between groups when compared by sex and age
(P > 0.05). Copy numbers and white blood cell counts in the peripheral blood of children with Chlamydia trachomatis in respiratory
secretions of the vaginal delivery group were significantly higher than those of the cesarean delivery group (P <0.05).Thealanine
aminotransferase and aspartate aminotransferase levels between groups were not statistically significant. Comparisons of admission
chest radiography scores, discharge radiography scores, and score differences showed no statistical differences (P > 0.05).
Conclusion: Infants delivered by cesarean comprise approximately one-fifth of those affected. The Chlamydia trachomatis
titers and peripheral blood leukocyte counts of the vaginal delivery group were higher than those of the cesarean delivery group.
Age of onset, liver enzymes, pulmonary inflammation, and pneumonia absorption were not different between groups.
What is Known:
• Chlamydia trachomatis is an important pathogen that causes lower respiratory tract infections in infants.
• C. trachomatis is primarily transmitted to infants through the infected mother, resulting in Chlamydia trachomatis pneumonia subsequently.
What is New:
• Vaginal delivery and cesarean delivery can result in Chlamydia trachomatis pneumonia transmission; however, cesarean delivery accounts for ~ 20% ofcases.
• C. trachomatis volume in the respiratory tract and the number of peripheral blood leukocytes in infants delivered vaginally were higher than those in
infants delivered by cesarean.
Keywords Chlamydia trachomatis
ALT Alanine aminotransferase
AST Aspartate aminotransferase
WHO World Health Organization
Chlamydia trachomatis pneumonia is caused by Chlamydia
trachomatis infection. Chlamydia trachomatis cannot metab-
olize by itself. It relies on host cells for energy, growth, and
reproduction; it is a class of parasites that infects epithelial
cells, endothelial cells, monocytes, macrophages, and other
cells within specific cells of internal protozoan microbes
[1, 2]. Chlamydia trachomatis can pass through commonly
Communicated by Peter de Winter
* Deyu Zhao
* Feng Liu
Children’s Hospital of Nanjing Medical University, Nanjing, China
Department of Respiration, Wuhan Children’s Hospital (Wuhan
Maternal and Child Healthcare Hospital), Tongji Medical College,
Huazhong University of Science & Technology, Wuhan, China
European Journal of Pediatrics