Influence of Dexamethasone on O-(2-[18F]-Fluoroethyl)-l-Tyrosine Uptake in the Human Brain and Quantification of Tumor Uptake

Influence of Dexamethasone on O-(2-[18F]-Fluoroethyl)-l-Tyrosine Uptake in the Human Brain and... 18 18 Purpose: O-(2-[ F]fluoroethyl)-L-tyrosine ([ F]FET) is an established positron emission tomography (PET) tracer for brain tumor imaging. This study explores the influence of dexamethasone therapy on [ F]FET uptake in the normal brain and its influence on the maximum and mean tumor-to-brain ratio (TBR). Procedures: [ F]FET PET scans of 160 brain tumor patients were evaluated (80 dexametha- sone treated, 80 untreated; each group with 40 men/40 women). The standardized uptake value of [ F]FET uptake in the normal brain (SUV ) in the different groups was compared. Nine brain patients were examined repeatedly with and without dexamethasone therapy. Results: SUV of [ F]FET uptake was significantly higher in dexamethasone-treated patients than in brain untreated patients (SUV 1.33 ± 0.1 versus 1.06 ± 0.16 in male and 1.45 ± 0.25 versus 1.31 ± 0.28 in brain female patients). Similar results were observed in patients with serial PET scans. Furthermore, compared to men, a significantly higher SUV was found in women, both with and without dexamethasone brain treatment. There were no significant differences between the different groups for TBR and TBR , max mean which could have been masked by the high standard deviation. In a patient with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Imaging and Biology Springer Journals

Influence of Dexamethasone on O-(2-[18F]-Fluoroethyl)-l-Tyrosine Uptake in the Human Brain and Quantification of Tumor Uptake

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Publisher
Springer Journals
Copyright
Copyright © 2018 by World Molecular Imaging Society
Subject
Medicine & Public Health; Imaging / Radiology
ISSN
1536-1632
eISSN
1860-2002
D.O.I.
10.1007/s11307-018-1221-z
Publisher site
See Article on Publisher Site

Abstract

18 18 Purpose: O-(2-[ F]fluoroethyl)-L-tyrosine ([ F]FET) is an established positron emission tomography (PET) tracer for brain tumor imaging. This study explores the influence of dexamethasone therapy on [ F]FET uptake in the normal brain and its influence on the maximum and mean tumor-to-brain ratio (TBR). Procedures: [ F]FET PET scans of 160 brain tumor patients were evaluated (80 dexametha- sone treated, 80 untreated; each group with 40 men/40 women). The standardized uptake value of [ F]FET uptake in the normal brain (SUV ) in the different groups was compared. Nine brain patients were examined repeatedly with and without dexamethasone therapy. Results: SUV of [ F]FET uptake was significantly higher in dexamethasone-treated patients than in brain untreated patients (SUV 1.33 ± 0.1 versus 1.06 ± 0.16 in male and 1.45 ± 0.25 versus 1.31 ± 0.28 in brain female patients). Similar results were observed in patients with serial PET scans. Furthermore, compared to men, a significantly higher SUV was found in women, both with and without dexamethasone brain treatment. There were no significant differences between the different groups for TBR and TBR , max mean which could have been masked by the high standard deviation. In a patient with

Journal

Molecular Imaging and BiologySpringer Journals

Published: May 29, 2018

References

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