J Cancer Res Clin Oncol (2017) 143:1637–1647 DOI 10.1007/s00432-017-2420-8 ORIGINAL ARTICLE – CANCER RESEARCH Increased trace amine‑associated receptor 1 (TAAR1) expression is associated with a positive survival rate in patients with breast cancer 1 1 1 1 1 4 Aurelia Vattai · Elif Akyol · Christina Kuhn · Simone Hofmann · Helene Heidegger · Franz von Koch · 1 1 1 5 2 3 Kerstin Hermelink · Rachel Wuerstlein · Nadia Harbeck · Doris Mayr · Christine Spitzweg · Bettina Toth · 1 1 1 Sven Mahner · Udo Jeschke · Nina Ditsch Received: 13 February 2017 / Accepted: 7 April 2017 / Published online: 13 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract variables were determined with Spearman’s rank correla- Purpose A correlation between breast cancer and thyroid tion coefficient. disorders has been described in previous studies. Degraded Results The investigation showed a correlation between thyroid hormones are referred to as trace amines. These TAAR1 expression and tumour differentiation grade. A endogenous amines have the ability to bind to the G-pro- well differentiated tumour grade (G1) was associated with tein-coupled receptor TAAR1 (trace amine-associated higher TAAR1 expression and HER2 and HER4 positiv- receptor) and thereby activate it. TAAR1
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 13, 2017
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