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Primuharsa, Putra, Sha, ohd, Razif, My, Marina (2008)
Carcinoma ex-pleomorphic adenoma, 6
M. Cabrera, R. Hollingsworth, E. Hurt (2015)
Cancer stem cell plasticity and tumor hierarchy.World journal of stem cells, 7 1
Margaret Brandwein, Margaret Brandwein, A. Huvos, Irving Dardick, Irving Dardick, M. Thomas, Neil Theise, Neil Theise (1996)
Noninvasive and minimally invasive carcinoma ex mixed tumor: a clinicopathologic and ploidy study of 12 patients with major salivary tumors of low (or no?) malignant potential.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 81 6
C. Scheel, R. Weinberg (2012)
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links.Seminars in cancer biology, 22 5-6
M Williams, S Ihrler, R Seethala (2017)
WHO classification of tumours
A. Krešo, J. Dick (2014)
Evolution of the cancer stem cell model.Cell stem cell, 14 3
P. Bareiss, Anna Paczulla, Hui Wang, Rebekka Schairer, S. Wiehr, U. Kohlhofer, Oliver Rothfuss, A. Fischer, S. Perner, A. Staebler, D. Wallwiener, F. Fend, T. Fehm, B. Pichler, L. Kanz, L. Quintanilla‐Martinez, K. Schulze-Osthoff, F. Essmann, C. Lengerke (2013)
SOX2 expression associates with stem cell state in human ovarian carcinoma.Cancer research, 73 17
S. Lee, S. Oh, S. Do, H. Lee, H. Kang, Y. Rho, W. Bae, Y. Lim (2014)
SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinomaBritish Journal of Cancer, 111
B. Sedassari, H. Santos, F. Mariano, N. Lascane, A. Altemani, S. Sousa (2015)
Carcinoma ex pleomorphic adenoma of minor salivary glands with major epithelial-myoepithelial component: clinicopathologic and immunohistochemical study of 3 cases.Annals of diagnostic pathology, 19 3
K. Olsen, Jean Lewis (2001)
Carcinoma ex pleomorphic adenoma: A clinicopathologic reviewHead & Neck, 23
M. Piva, G. Domenici, Oihana Iriondo, Miriam Rábano, Bruno Simões, Valentine Comaills, I. Barredo, J. Lopez-Ruiz, I. Zabalza, R. Kypta, M. Vivanco (2013)
Sox2 promotes tamoxifen resistance in breast cancer cellsEMBO Molecular Medicine, 6
F. Greene, D. Page, I. Fleming, J. Fritz, C. Balch, D. Haller (2002)
AJCC Cancer Staging Manual. 6th ed
S. Olphen, K. Biermann, M. Spaander, F. Kastelein, E. Steyerberg, Hans Stoop, M. Bruno, L. Looijenga (2015)
SOX2 as a Novel Marker to Predict Neoplastic Progression in Barrett’s EsophagusThe American Journal of Gastroenterology, 110
W. Dai, Xue-xin Tan, Changfu Sun, Qing Zhou (2014)
High Expression of SOX2 Is Associated with Poor Prognosis in Patients with Salivary Gland Adenoid Cystic CarcinomaInternational Journal of Molecular Sciences, 15
Yu-Hua Huang, Minghua Luo, Yun-bi Ni, J. Tsang, Siu-Ki Chan, P. Lui, A. Yu, P. Tan, G. Tse (2014)
Increased SOX2 expression in less differentiated breast carcinomas and their lymph node metastasesHistopathology, 64
Jing Ji, Peng‐Sheng Zheng (2010)
Expression of Sox2 in human cervical carcinogenesis.Human pathology, 41 10
G. Ellis, P. Auclair (1996)
Tumors of the Salivary Glands
A. Alizadeh, S. Shiri, Sadaf Farsinejad (2014)
Metastasis review: from bench to bedsideTumor Biology, 35
H. Brustmann, A. Brunner (2013)
Immunohistochemical Expression of SOX2 in Vulvar Intraepithelial Neoplasia and Squamous Cell CarcinomaInternational Journal of Gynecological Pathology, 32
Y. Hirohashi, T. Torigoe, S. Inoda, A. Takahashi, R. Morita, S. Nishizawa, Y. Tamura, Hiromu Suzuki, M. Toyota, N. Sato (2010)
Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells.Immunotherapy, 2 2
R. Spiro, A. Huvos, E. Strong (1977)
Malignant mixed tumor of salivary origin. A clinicopathologic study of 146 casesCancer, 39
Kuancan Liu, Bao-shun Lin, Meng Zhao, Xiangyue Yang, Min Chen, Anding Gao, Fei Liu, J. Que, X. Lan (2013)
The multiple roles for Sox2 in stem cell maintenance and tumorigenesis.Cellular signalling, 25 5
Y. Sanada, Kazuhiro Yoshida, M. Ôhara, Mamoru Oeda, K. Konishi, Y. Tsutani (2006)
Histopathologic Evaluation of Stepwise Progression of Pancreatic Carcinoma with Immunohistochemical Analysis of Gastric Epithelial Transcription Factor SOX2: Comparison of Expression Patterns between Invasive Components and Cancerous or Nonneoplastic Intraductal ComponentsPancreas, 32
Xiabing Tang, Xiaozhou Shen, Lei Li, Yi-fen Zhang, Guo-qian Chen (2013)
SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma.Auris, nasus, larynx, 40 5
C. Weiler, P. Zengel, J. Wal, O. Guntinas-Lichius, S. Schwarz, J. Harrison, T. Kirchner, S. Ihrler (2011)
Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation of 41 casesHistopathology, 59
P. Yuan, H. Kadara, C. Behrens, Ximing Tang, Denise Woods, L. Solis, Jiaoti Huang, M. Spínola, W. Dong, G. Yin, J. Fujimoto, Edward Kim, Yang Xie, L. Girard, C. Moran, W. Hong, J. Minna, I. Wistuba (2010)
Sex Determining Region Y-Box 2 (SOX2) Is a Potential Cell-Lineage Gene Highly Expressed in the Pathogenesis of Squamous Cell Carcinomas of the LungPLoS ONE, 5
GL Ellis, PL Auclair (2008)
Atlas of tumor pathology
J. Lüers, C. Wittekindt, M. Streppel, O. Guntinas-Lichius (2009)
Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapyActa Oncologica, 48
P. Hermann, Stephan Huber, T. Herrler, A. Aicher, J. Ellwart, M. Guba, C. Bruns, C. Heeschen (2007)
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.Cell stem cell, 1 3
Xiaofang Liu, Wen-Ting Yang, R. Xu, Jun-tian Liu, Peng‐Sheng Zheng (2014)
Cervical Cancer Cells with Positive Sox2 Expression Exhibit the Properties of Cancer Stem CellsPLoS ONE, 9
Y. Chou, Chih-Chan Lee, S. Hsiao, Sey‐En Lin, Sheng‐Chieh Lin, Chih-Hung Chung, Chi-Hsiu Chung, Yu-Rong Kao, Yuan-Hung Wang, Chien‐Tsun Chen, Yau-Huei Wei, Cheng-Wen Wu (2013)
The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung CancerSTEM CELLS, 31
Abby Sarkar, K. Hochedlinger (2013)
The sox family of transcription factors: versatile regulators of stem and progenitor cell fate.Cell stem cell, 12 1
P. Ellis, B. Fagan, S. Magness, Scott Hutton, O. Taranova, S. Hayashi, A. McMahon, M. Rao, L. Pevny (2004)
SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the AdultDevelopmental Neuroscience, 26
Y Hirohashi, T Torigoe, S Inoda (2010)
Immune response against tumor antigens expressed on humanImmunotherapy, 2
Yuhua Hu, Chun-ye Zhang, R. Xia, Z. Tian, Li-Zhen Wang, Jiang Li (2016)
Prognostic factors of carcinoma ex pleomorphic adenoma of the salivary glands, with emphasis on the widely invasive carcinoma: a clinicopathologic analysis of 361 cases in a Chinese population.Oral surgery, oral medicine, oral pathology and oral radiology, 122 5
Jean Lewis, K. Olsen, T. Sebo (2001)
Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases.Human pathology, 32 6
E. Martinez, N. Araújo, V. Araújo (2015)
How do benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma favor tumor progression?Journal of Cell Communication and Signaling, 9
Chongmin Ren, T. Ren, Kang Yang, Shidong Wang, Xing Bao, Fan Zhang, Wei Guo (2016)
Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathwayJournal of Experimental & Clinical Cancer Research : CR, 35
S. Dawood, Laura Austin, M. Cristofanilli (2014)
Cancer stem cells: implications for cancer therapy.Oncology, 28 12
M. Herreros-Villanueva, M. Herreros-Villanueva, J.-S. Zhang, A. Koenig, A. Koenig, Ethan Abel, T. Smyrk, W. Bamlet, A. Narvajas, T. Gomez, D. Simeone, L. Bujanda, D. Billadeau (2013)
SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cellsOncogenesis, 2
M. Amin, S. Edge, F. Greene, D. Byrd, R. Brookland, M. Washington, J. Gershenwald, C. Compton, K. Hess, D. Sullivan, J. Jessup, J. Brierley, L. Gaspar, R. Schilsky, C. Balch, D. Winchester, Elliot Asare, M. Madera, Donna Gress, L. Meyer (2002)
AJCC Cancer Staging Manual
O. Leis, Arrate Eguiara, E. López-Arribillaga, M. Alberdi, Susana Hernández-García, K. Elorriaga, A. Pandiella, R. Rezola, Angel Martín (2012)
Sox2 expression in breast tumours and activation in breast cancer stem cellsOncogene, 31
A. Altemani, M. Martins, L. Freitas, F. Soares, N. Araújo, V. Araújo (2005)
Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progressionHistopathology, 46
V. Livolsi, K. Perzin (1977)
Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: A clinicopathologic studyCancer, 39
SOX2 is a regulatory factor of embryonic stem cells that has been implicated in carcinogenesis and cancer progression. We aimed to investigate the potential role of SOX2 in the stepwise progression from pleomorphic adenoma (PA) to invasive carcinoma ex pleomorphic adenoma (CXPA), evaluating its prognostic significance as well. Thirty PAs without malignant transformation and 25 CXPAs presenting both luminal or myoepithelial differentiation (7 intracapsular and 18 extracapsular) were evaluated immunohistochemically for SOX2 expression. Of these, 24 CXPAs (96%) were positive to SOX2, being 6 intracapsular carcinomas (85.7%) and all the 18 extracapsular carcinomas (100%). Residual PA areas and PA without malignant transformation were negative. High SOX2 expression levels (> 50% of positive cells) were correlated with high histological grade (p = 0.02), brisk mitotic activity (p = 0.01), advanced pT stage (p = 0.01), tumor recurrence (p = 0.01), and development of distant metastasis (p = 0.004). Still, overall survival rates were shorter in patients with extracapsular CXPA exhibiting diffuse SOX2 expression. These results suggest that SOX2 may play an important role in carcinogenesis and progression of CXPA and is also related with prognostic indicators in CXPAs with extracapsular invasion. Although direct therapeutic intervention in SOX2 may result in unwanted complications due to its constitutive functions, strategic approach to SOX2-related pathways may provide new therapeutic opportunities for patients with invasive CXPA.
Virchows Archiv – Springer Journals
Published: Aug 25, 2017
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