Reactions 1680, p11 - 2 Dec 2017 Increased risk of psoriasis with terbinafine, itraconazole There is an increased risk of psoriasis in patients who have been exposed to the antifungal agents terbinafine or itraconazole, according to Taiwanese researchers. Researchers from the National Taiwan University utilised data from the National Health Insurance Research Database to identify patients with onychomycosis who had experienced cases of incident psoriasis during 2004 and 2010. A total of 3831 such patients were identified, as well as an identical number of matched controls. Compared with the matched controls, patients who had developed psoriasis were significantly more likely to have used terbinafine (>59%) or itraconazole (>42%). After adjusting for potential confounders and cumulative duration of antifungal drug prescription, use of terbinafine or itraconazole was associated with an increased risk of incident psoriasis (odds ratio [OR] 1.33; 95% CI 1.15, 1.54), and this association was found to be even stronger with more recent exposure to these drugs (OR 2.96; 95% CI 2.25, 3.90). Furthermore, when the individual drug risks were assessed, it was found that the risk of psoriasis was higher for itraconazole users, versus terbinafine users. The researchers highlighted that "future prospective studies should investigate if terbinafine or itraconazole use induces de novo psoriasis or aggravates pre-existing psoriasis, and if [the] psoriasis risk is lower for terbinafine than for itraconazole". They also noted that at present, the mechanisms via which itraconazole or terbinafine may cause psoriasis remain unclear. Chiu HY, et al. Risk of Psoriasis Following Terbinafine or Itraconazole Treatment for Onychomycosis: A Population-Based Case-Control Comparative Study. Drug Safety : 6 Nov 2017. Available from: URL: https://link.springer.com/ article/10.1007/s40264-017-0614-2 803284959 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680
Reactions Weekly – Springer Journals
Published: Dec 2, 2017
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