Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Increased risk of myocardial infarction with PPIs?

Increased risk of myocardial infarction with PPIs? Reactions 1680, p9 - 2 Dec 2017 Increased risk of myocardial infarction with PPIs? There is no evidence that prescribing proton pump inhibitors (PPIs) increases the risk of myocardial infarction (MI) compared with prescribing histamine-2 receptor antagonists (H2RAs), according to study results reported in Gastroenterology, and "physicians and patients should not avoid starting a PPI because of concerns related to MI risk". The observational cohort study used the US Truven Health Analytics MarketScan Research Database. Claims from eligible adults who started new prescriptions for PPIs or H2RAs in 2001–2014 were identified. The Commercial Claims and Encounters database included 3675 120 patients who received PPIs and 829 441 patients who received H2RAs, while the Medicare Supplemental database identified 894 821 patients who received PPIs and 192 607 patients who received H2RAs. The primary outcome was hospitalised MI. In the commercial claims cohort, the crude MI risk increased over the time of the study. The 3-month risk for PPI compared with H2RA recipients was "essentially null," note the authors (weighted risk ratio [RR] 1.00; 95% CI 0.87, 1.16), and remained approximately null for other timepoints. At 12 months, there was a slight but insignificantly decreased risk of MI per 1000 PPI http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Increased risk of myocardial infarction with PPIs?

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017

Increased risk of myocardial infarction with PPIs?

Abstract

Reactions 1680, p9 - 2 Dec 2017 Increased risk of myocardial infarction with PPIs? There is no evidence that prescribing proton pump inhibitors (PPIs) increases the risk of myocardial infarction (MI) compared with prescribing histamine-2 receptor antagonists (H2RAs), according to study results reported in Gastroenterology, and "physicians and patients should not avoid starting a PPI because of concerns related to MI risk". The observational cohort study used the US Truven Health...
Loading next page...
1
 
/lp/springer_journal/increased-risk-of-myocardial-infarction-with-ppis-pSXQ68xc0n

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-017-38940-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p9 - 2 Dec 2017 Increased risk of myocardial infarction with PPIs? There is no evidence that prescribing proton pump inhibitors (PPIs) increases the risk of myocardial infarction (MI) compared with prescribing histamine-2 receptor antagonists (H2RAs), according to study results reported in Gastroenterology, and "physicians and patients should not avoid starting a PPI because of concerns related to MI risk". The observational cohort study used the US Truven Health Analytics MarketScan Research Database. Claims from eligible adults who started new prescriptions for PPIs or H2RAs in 2001–2014 were identified. The Commercial Claims and Encounters database included 3675 120 patients who received PPIs and 829 441 patients who received H2RAs, while the Medicare Supplemental database identified 894 821 patients who received PPIs and 192 607 patients who received H2RAs. The primary outcome was hospitalised MI. In the commercial claims cohort, the crude MI risk increased over the time of the study. The 3-month risk for PPI compared with H2RA recipients was "essentially null," note the authors (weighted risk ratio [RR] 1.00; 95% CI 0.87, 1.16), and remained approximately null for other timepoints. At 12 months, there was a slight but insignificantly decreased risk of MI per 1000 PPI

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

There are no references for this article.