Incorporation of delivery times in stereotactic radiosurgery treatment optimization

Incorporation of delivery times in stereotactic radiosurgery treatment optimization Although the use of mathematical optimization techniques can greatly improve the quality of treatment plans in various radiation therapy treatment settings, one complication is the potentially clinically unrealistic nature of optimized treatments. The difficulty arises from two factors: (1) machine limitations that govern the minimum amount of radiation delivery time, and (2) long treatment times due to the complexity of optimized treatments. In the first scenario, if a particular configuration of the radiation delivery device is used, then it typically must deliver radiation for a minimum length of time. Incorporation of such requirements in a mathematical model generally requires additional constraints and binary variables, increasing the difficulty of the optimization. In the second scenario, mathematically optimized treatments commonly assign (small amounts of) radiation to be delivered from many configurations, drastically increasing the time needed to deliver the treatment (beam-on time). We examine these two issues within the penalty-based sector duration optimization model for Leksell Gamma Knife $$^{\textregistered }$$ ® Perfexion $$^{\mathrm{TM}}$$ TM (Elekta, Stockholm, Sweden) and the combined sector duration and isocentre optimization model to reduce beam-on time and to ensure that machine limitations regarding delivery times are met. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Global Optimization Springer Journals

Incorporation of delivery times in stereotactic radiosurgery treatment optimization

Loading next page...
 
/lp/springer_journal/incorporation-of-delivery-times-in-stereotactic-radiosurgery-treatment-bHb08e60jt
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Mathematics; Optimization; Operations Research/Decision Theory; Real Functions; Computer Science, general
ISSN
0925-5001
eISSN
1573-2916
D.O.I.
10.1007/s10898-017-0527-8
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial