Incidence, risk factors, and outcome of neonatal acute kidney injury: a prospective cohort study

Incidence, risk factors, and outcome of neonatal acute kidney injury: a prospective cohort study Background Acute kidney injury (AKI) is common in neonates admitted to the neonatal intensive care unit (NICU). AKI is associated with increased morbidity and mortality and a greater long-term risk of chronic kidney disease. Objectives To study the incidence and outcome of neonatal AKI in a single Saudi Arabian center, level 2\3 NICU. Methods This single-center prospective cohort study included all infants who received level II or III NICU care during 2015 (January to December). We excluded infants who survived less than 48 h after admission, had evidence of congenital renal anomalies, or had insufficient data. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Both AKI and non-AKI neonates were prospectively followed up until NICU discharge. Outcomes studied included mortality and length of NICU stay. The results of adjusted risk analyses were expressed as relative risk (RR) with 95% confidence interval (95% CI). Results The incidence of AKI (modified neonatal KDIGO stages) was 56% (120/214 patients). Compared with neonates without AKI, those with AKI had a lower birth weight (2202 ± 816 vs. 1570 ± 776 g; p < 0.001) and a lower gestational age (35 ± 3 vs. 32 ± 4 weeks; p http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Nephrology Springer Journals

Incidence, risk factors, and outcome of neonatal acute kidney injury: a prospective cohort study

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Publisher
Springer Journals
Copyright
Copyright © 2018 by IPNA
Subject
Medicine & Public Health; Pediatrics; Nephrology; Urology
ISSN
0931-041X
eISSN
1432-198X
DOI
10.1007/s00467-018-3966-7
Publisher site
See Article on Publisher Site

Abstract

Background Acute kidney injury (AKI) is common in neonates admitted to the neonatal intensive care unit (NICU). AKI is associated with increased morbidity and mortality and a greater long-term risk of chronic kidney disease. Objectives To study the incidence and outcome of neonatal AKI in a single Saudi Arabian center, level 2\3 NICU. Methods This single-center prospective cohort study included all infants who received level II or III NICU care during 2015 (January to December). We excluded infants who survived less than 48 h after admission, had evidence of congenital renal anomalies, or had insufficient data. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Both AKI and non-AKI neonates were prospectively followed up until NICU discharge. Outcomes studied included mortality and length of NICU stay. The results of adjusted risk analyses were expressed as relative risk (RR) with 95% confidence interval (95% CI). Results The incidence of AKI (modified neonatal KDIGO stages) was 56% (120/214 patients). Compared with neonates without AKI, those with AKI had a lower birth weight (2202 ± 816 vs. 1570 ± 776 g; p < 0.001) and a lower gestational age (35 ± 3 vs. 32 ± 4 weeks; p

Journal

Pediatric Nephrology – Springer Journals

Published: Jun 5, 2018

References

  • Neonatal acute kidney injury
    Selewski, DT; Charlton, JR; Jetton, JG; Guillet, R; Mhanna, MJ; Askenazi, DJ; Kent, AL
  • Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study
    Jetton, JG; Boohaker, LJ; Sethi, SK; Wazir, S; Rohatgi, S; Soranno, DE; Chishti, AS; Woroniecki, R; Mammen, C; Swanson, JR; Sridhar, S; Wong, CS; Kupferman, JC; Griffin, RL; Askenazi, DJ
  • Critical serum creatinine values in very preterm newborns
    Bruel, A; Roze, JC; Flamant, C; Simeoni, U; Roussey-Kesler, G; lain-Launay, E
  • Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions
    Cuzzolin, L; Fanos, V; Pinna, B; di, MM; Perin, M; Tramontozzi, P; Tonetto, P; Cataldi, L
  • Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Mehta, RL; Kellum, JA; Shah, SV; Molitoris, BA; Ronco, C; Warnock, DG; Levin, A
  • KDIGO clinical practice guidelines for acute kidney injury
    Khwaja, A
  • The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. The International Neonatal Network
    Anonymous
  • Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population
    Selewski, DT; Cornell, TT; Heung, M; Troost, JP; Ehrmann, BJ; Lombel, RM; Blatt, NB; Luckritz, K; Hieber, S; Gajarski, R; Kershaw, DB; Shanley, TP; Gipson, DS
  • Developing a neonatal acute kidney injury research definition: a report from the NIDDK neonatal AKI workshop
    Zappitelli, M; Ambalavanan, N; Askenazi, DJ; Moxey-Mims, MM; Kimmel, PL; Star, RA; Abitbol, CL; Brophy, PD; Hidalgo, G; Hanna, M; Morgan, CM; Raju, TNK; Ray, P; Reyes-Bou, Z; Roushdi, A; Goldstein, SL
  • Reference ranges for serum creatinine in infants, children and adolescents
    Savory, DJ
  • Update on acute kidney injury in the neonate
    Jetton, JG; Askenazi, DJ
  • Acute kidney injury in the fetus and neonate
    Nada, A; Bonachea, EM; Askenazi, DJ
  • Defining reduced urine output in neonatal ICU: importance for mortality and acute kidney injury classification
    Bezerra, CT; Vaz Cunha, LC; Liborio, AB
  • Acute renal failure in the newborn
    Andreoli, SP
  • Acute kidney injury in preterm infants admitted to a neonatal intensive care unit
    Stojanovic, V; Barisic, N; Milanovic, B; Doronjski, A
  • Acute kidney injury is independently associated with mortality in very low birthweight infants: a matched case-control analysis
    Askenazi, DJ; Griffin, R; McGwin, G; Carlo, W; Ambalavanan, N
  • Fluid overload and mortality are associated with acute kidney injury in sick near-term/term neonate
    Askenazi, DJ; Koralkar, R; Hundley, HE; Montesanti, A; Patil, N; Ambalavanan, N
  • Acute kidney injury in a single neonatal intensive care unit in Turkey
    Bolat, F; Comert, S; Bolat, G; Kucuk, O; Can, E; Bulbul, A; Uslu, HS; Nuhoglu, A
  • Acute renal failure in neonatal sepsis
    Mathur, NB; Agarwal, HS; Maria, A
  • Recognition and reporting of AKI in very low birth weight infants
    Carmody, JB; Swanson, JR; Rhone, ET; Charlton, JR
  • Acute kidney injury reduces survival in very low birth weight infants
    Koralkar, R; Ambalavanan, N; Levitan, EB; McGwin, G; Goldstein, S; Askenazi, D
  • Incidence and outcomes of acute kidney injury in extremely-low-birth-weight infants
    Lee, CC; Chan, OW; Lai, MY; Hsu, KH; Wu, TW; Lim, WH; Wang, YC; Lien, R
  • Nephrotoxic medication exposure in very low birth weight infants
    Rhone, ET; Carmody, JB; Swanson, JR; Charlton, JR
  • Acute renal failure in the neonatal period
    Agras, PI; Tarcan, A; Baskin, E; Cengiz, N; Gurakan, B; Saatci, U
  • Prognostic factors in neonatal acute renal failure
    Chevalier, RL; Campbell, F; Brenbridge, AN
  • Acute peritoneal dialysis in the newborn period: a 7-year single-center experience at tertiary neonatal intensive care unit in Turkey
    Hakan, N; Aydin, M; Zenciroglu, A; Aydog, O; Erdogan, D; Karagol, BS; Dursun, A; Okumus, N
  • Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: a prospective multicenter study
    Li, S; Krawczeski, CD; Zappitelli, M; Devarajan, P; Thiessen-Philbrook, H; Coca, SG; Kim, RW; Parikh, CR
  • Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: a prospective cohort study
    Mammen, C; Al, AA; Skippen, P; Nadel, H; Levine, D; Collet, JP; Matsell, DG
  • A developmental approach to the prevention of hypertension and kidney disease: a report from the low birth weight and nephron number working group
    Luyckx, VA; Perico, N; Somaschini, M; Manfellotto, D; Valensise, H; Cetin, I; Simeoni, U; Allegaert, K; Vikse, BE; Steegers, EA; Adu, D; Montini, G; Remuzzi, G; Brenner, BM

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