Mammalian Genome 10, 645–648 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Inbred lines of mice derived from long-term divergent selection on fat content and body weight Lutz Bu ¨ nger, William G. Hill Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK Received: 9 November 1998 / Accepted: 12 January 1999 For identification of the genetic and physiological basis of growth Derivation of (outbred) selection lines. Selection lines were initi- and fatness, the establishment of inbred lines derived from diver- ated in this laboratory in Edinburgh from a 3-way cross (two gently selected lines is an important tool (Lander and Botstein inbred [CBA, JU] and one outbred line [CFLP]) base (Sharp et al. 1989; Festing 1997). It is necessary, first, to develop highly diver- 1984). Lines (P, or protein lines) were divergently selected for 20 gent selection lines for the traits of interest, and then to derive generations for high (EPH) and low (EPL) lean mass, estimated inbred lines from them. In this paper the origins and characteristics from an index of body weight and gonadal fat pad weight in males. are described of two pairs of such
Mammalian Genome – Springer Journals
Published: Mar 11, 2014
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