Inactivation and morphological changes of avian influenza virus by copper ions

Inactivation and morphological changes of avian influenza virus by copper ions The infectivity of the H9N2 virus to MDCK cells was time-dependently inhibited by Cu 2+ at concentrations of 2.5–250 μM. In 25 μM Cu 2+ solution, the virus titer decreased by approximately 3 and 4 log within 3 and 6 h, respectively. Compared to Cu 2+ , Zn 2+ was much less effective in virus inactivation. The H9N2 virus hemagglutinin activity was not affected by 2.5–250 μM Cu 2+ . The H9N2 virus neuraminidase (NA) activity was drastically reduced by 25 mM Cu 2+ , marginally reduced by 250 μM Cu 2+ , and not affected by 25 μM Cu 2+ . Thus, we found that copper ions suppress the infectivity of influenza virus at lower concentrations at which neither NA nor hemagglutination inhibition occurs. Electron microscopic analysis revealed morphological abnormalities of the Cu 2+ -treated H9N2 virus. Additional studies should be undertaken to clarify the mechanism underlying the antiviral effect of copper ions on influenza virus. Archives of Virology Springer Journals

Inactivation and morphological changes of avian influenza virus by copper ions

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Springer Vienna
Copyright © 2008 by Springer-Verlag
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
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