The infectivity of the H9N2 virus to MDCK cells was time-dependently inhibited by Cu 2+ at concentrations of 2.5–250 μM. In 25 μM Cu 2+ solution, the virus titer decreased by approximately 3 and 4 log within 3 and 6 h, respectively. Compared to Cu 2+ , Zn 2+ was much less effective in virus inactivation. The H9N2 virus hemagglutinin activity was not affected by 2.5–250 μM Cu 2+ . The H9N2 virus neuraminidase (NA) activity was drastically reduced by 25 mM Cu 2+ , marginally reduced by 250 μM Cu 2+ , and not affected by 25 μM Cu 2+ . Thus, we found that copper ions suppress the infectivity of influenza virus at lower concentrations at which neither NA nor hemagglutination inhibition occurs. Electron microscopic analysis revealed morphological abnormalities of the Cu 2+ -treated H9N2 virus. Additional studies should be undertaken to clarify the mechanism underlying the antiviral effect of copper ions on influenza virus.
Archives of Virology – Springer Journals
Published: Aug 1, 2008
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