In vivo immunological properties research on mesenchymal stem cells based engineering cartilage by a dialyzer pocket model

In vivo immunological properties research on mesenchymal stem cells based engineering cartilage... implantation, respectively. The results showed that collagen hydrogel can induce MSCs to form cartilage tissue, followed by alteration of immunological properties. In muscle implantation, relatively low expression of major histo- compatibility complex (MHC) molecules and low level of one-way mixed lymphocyte reactions (MLR) on the seeded MSCs were observed, but only a little cartilage tissue formed. In articular cavity implantation, more cartilage tissue formed, but higher MHC expressions and MLR level were found. Results indicated that the immunomodulation and the * Jie Liang * Yujiang Fan Tun Yuan ● ● Keywords Mesenchymal stem cells Collagen hydrogen ● ● Cartilage tissue engineering Immunological properties Hongrong Luo chondrogenesis Likun Guo 1 Introduction Hongsong Fan Xingdong Zhang Mesenchymal stem cells (MSCs) are one of the common seeded cells in tissue engineering [1]. Unlike the cells which hold a determined direction of differentiation, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China MSCs have multi-directional differentiation capability [2, 3]. 150 Page 2 of 8 J Mater Sci: Mater Med (2017) 28:150 The suitable scaffolds, such as collagen hydrogel can induce would offer more information on the immune properties of MSCs to form cartilage in vitro Journal of Materials Science: Materials in Medicine Springer Journals

In vivo immunological properties research on mesenchymal stem cells based engineering cartilage by a dialyzer pocket model

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Springer US
Copyright © 2017 by Springer Science+Business Media, LLC
Materials Science; Biomaterials; Biomedical Engineering; Regenerative Medicine/Tissue Engineering; Polymer Sciences; Ceramics, Glass, Composites, Natural Materials; Surfaces and Interfaces, Thin Films
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