In vivo immunological properties research on mesenchymal stem cells based engineering cartilage by a dialyzer pocket model

In vivo immunological properties research on mesenchymal stem cells based engineering cartilage... implantation, respectively. The results showed that collagen hydrogel can induce MSCs to form cartilage tissue, followed by alteration of immunological properties. In muscle implantation, relatively low expression of major histo- compatibility complex (MHC) molecules and low level of one-way mixed lymphocyte reactions (MLR) on the seeded MSCs were observed, but only a little cartilage tissue formed. In articular cavity implantation, more cartilage tissue formed, but higher MHC expressions and MLR level were found. Results indicated that the immunomodulation and the * Jie Liang Jie_l88@126.com * Yujiang Fan yujiang.fan@163.com Tun Yuan ● ● Keywords Mesenchymal stem cells Collagen hydrogen Stalight@163.com ● ● Cartilage tissue engineering Immunological properties Hongrong Luo chondrogenesis luohrcd@yahoo.com Likun Guo lkgchem@hotmail.com 1 Introduction Hongsong Fan hsfan@scu.edu.cn Xingdong Zhang Mesenchymal stem cells (MSCs) are one of the common zhangxd@scu.edu.cn seeded cells in tissue engineering [1]. Unlike the cells which hold a determined direction of differentiation, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China MSCs have multi-directional differentiation capability [2, 3]. 150 Page 2 of 8 J Mater Sci: Mater Med (2017) 28:150 The suitable scaffolds, such as collagen hydrogel can induce would offer more information on the immune properties of MSCs to form cartilage in vitro http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Materials Science: Materials in Medicine Springer Journals

In vivo immunological properties research on mesenchymal stem cells based engineering cartilage by a dialyzer pocket model

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Materials Science; Biomaterials; Biomedical Engineering; Regenerative Medicine/Tissue Engineering; Polymer Sciences; Ceramics, Glass, Composites, Natural Materials; Surfaces and Interfaces, Thin Films
ISSN
0957-4530
eISSN
1573-4838
D.O.I.
10.1007/s10856-017-5955-y
Publisher site
See Article on Publisher Site

Abstract

implantation, respectively. The results showed that collagen hydrogel can induce MSCs to form cartilage tissue, followed by alteration of immunological properties. In muscle implantation, relatively low expression of major histo- compatibility complex (MHC) molecules and low level of one-way mixed lymphocyte reactions (MLR) on the seeded MSCs were observed, but only a little cartilage tissue formed. In articular cavity implantation, more cartilage tissue formed, but higher MHC expressions and MLR level were found. Results indicated that the immunomodulation and the * Jie Liang Jie_l88@126.com * Yujiang Fan yujiang.fan@163.com Tun Yuan ● ● Keywords Mesenchymal stem cells Collagen hydrogen Stalight@163.com ● ● Cartilage tissue engineering Immunological properties Hongrong Luo chondrogenesis luohrcd@yahoo.com Likun Guo lkgchem@hotmail.com 1 Introduction Hongsong Fan hsfan@scu.edu.cn Xingdong Zhang Mesenchymal stem cells (MSCs) are one of the common zhangxd@scu.edu.cn seeded cells in tissue engineering [1]. Unlike the cells which hold a determined direction of differentiation, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China MSCs have multi-directional differentiation capability [2, 3]. 150 Page 2 of 8 J Mater Sci: Mater Med (2017) 28:150 The suitable scaffolds, such as collagen hydrogel can induce would offer more information on the immune properties of MSCs to form cartilage in vitro

Journal

Journal of Materials Science: Materials in MedicineSpringer Journals

Published: Aug 22, 2017

References

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