implantation, respectively. The results showed that collagen hydrogel can induce MSCs to form cartilage tissue, followed by alteration of immunological properties. In muscle implantation, relatively low expression of major histo- compatibility complex (MHC) molecules and low level of one-way mixed lymphocyte reactions (MLR) on the seeded MSCs were observed, but only a little cartilage tissue formed. In articular cavity implantation, more cartilage tissue formed, but higher MHC expressions and MLR level were found. Results indicated that the immunomodulation and the * Jie Liang Jie_l88@126.com * Yujiang Fan email@example.com Tun Yuan ● ● Keywords Mesenchymal stem cells Collagen hydrogen Stalight@163.com ● ● Cartilage tissue engineering Immunological properties Hongrong Luo chondrogenesis firstname.lastname@example.org Likun Guo email@example.com 1 Introduction Hongsong Fan firstname.lastname@example.org Xingdong Zhang Mesenchymal stem cells (MSCs) are one of the common email@example.com seeded cells in tissue engineering . Unlike the cells which hold a determined direction of differentiation, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China MSCs have multi-directional differentiation capability [2, 3]. 150 Page 2 of 8 J Mater Sci: Mater Med (2017) 28:150 The suitable scaffolds, such as collagen hydrogel can induce would offer more information on the immune properties of MSCs to form cartilage in vitro
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Aug 22, 2017
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