J Mater Sci: Mater Med (2017) 28:114 DOI 10.1007/s10856-017-5923-6 CLINICAL APPLICATIONS OF BIOMATERIALS Original Research In vivo evaluation of the bone integration of coated poly (vinyl-alcohol) hydrogel ﬁber implants 1,2 1,3 3 1 ● ● ● ● David Moreau Arthur Villain Manon Bachy Henry Proudhon 4 3 3 1,2 ● ● ● David N. Ku Didier Hannouche Hervé Petite Laurent Corté Received: 18 November 2016 / Accepted: 7 June 2017 © Springer Science+Business Media, LLC 2017 Abstract Recently, it has been shown that constructs of method is proposed to quantify the thickness of this ﬁbrous poly(vinyl alcohol) (PVA) hydrogel ﬁbers reproduce clo- capsule. Implants coated with HA were not signiﬁcantly sely the tensile behavior of ligaments. However, the bio- osteoconductive, which can be attributed to the slow dis- logical response to these systems has not been explored yet. solution of the selected hydroxyapatite. Overall, these Here, we report the ﬁrst in vivo evaluation of these implants results conﬁrm the relevance of PVA hydrogel ﬁbers for and focus on the integration in bone, using a rabbit model of ligament reconstruction and adjustments are proposed to bone tunnel healing. Implants consisted in bundles of PVA enhance its osseointegration. hydrogel ﬁbers embedded
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Jun 19, 2017
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