In Silico Identification and Characterization of Meiotic DNA: AluJb Possibly Participates in the Attachment of Chromatin Loops to Synaptonemal Complex

In Silico Identification and Characterization of Meiotic DNA: AluJb Possibly Participates in the... Earlier, using bioinformatic methods, we reported the identification of repeated DNA sequences (RSs), presumably responsible for the attachment of chromatin loops to the lateral elements of synaptonemal complex in meiotic chromosomes. In the present study, consensus sequences for this class of RS were identified. It was demonstrated that at least part of these sequences belonged to the AluJb subfamily of Alu sequences. The Alu copies distribution along the major human histocompatibility complex (MHC) and their spatial separation from the sites of meiotic recombination was examined. It was demonstrated that simple sequences, like (GT/CA) n , were flanking meiotic recombination sites. A model of the RS organization in meiotic chromosome, most efficiently linking experimental data on the meiotic recombination in MHC and the in silico data on the RS localization (the coefficient of multiple correlation, r = 0.92) is suggested. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

In Silico Identification and Characterization of Meiotic DNA: AluJb Possibly Participates in the Attachment of Chromatin Loops to Synaptonemal Complex

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Publisher
Springer Journals
Copyright
Copyright © 2005 by MAIK "Nauka/Interperiodica"
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1007/s11177-006-0016-5
Publisher site
See Article on Publisher Site

Abstract

Earlier, using bioinformatic methods, we reported the identification of repeated DNA sequences (RSs), presumably responsible for the attachment of chromatin loops to the lateral elements of synaptonemal complex in meiotic chromosomes. In the present study, consensus sequences for this class of RS were identified. It was demonstrated that at least part of these sequences belonged to the AluJb subfamily of Alu sequences. The Alu copies distribution along the major human histocompatibility complex (MHC) and their spatial separation from the sites of meiotic recombination was examined. It was demonstrated that simple sequences, like (GT/CA) n , were flanking meiotic recombination sites. A model of the RS organization in meiotic chromosome, most efficiently linking experimental data on the meiotic recombination in MHC and the in silico data on the RS localization (the coefficient of multiple correlation, r = 0.92) is suggested.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Jan 17, 2006

References

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