In Memoriam: Lawrence A. Frohman, M.D. January 26, 1935–March 4, 2018

In Memoriam: Lawrence A. Frohman, M.D. January 26, 1935–March 4, 2018 Pituitary https://doi.org/10.1007/s11102-018-0896-0 In Memoriam: Lawrence A. Frohman, M.D. January 26, 1935–March 4, 1 2 Seymour Reichlin  · Mark E. Molitch © Springer Science+Business Media, LLC, part of Springer Nature 2018 hormone (GH). He provided important early information regarding the hypothalamic regulation of GH secretion. Later, he identified and partially purified a GH releasing hormone (GHRH) from pancreatic and lung tumors, which eventually led to isolation and sequencing of the hormone. He published extensively on GHRH gene expression, secre- tion, and action. Larry also initiated studies in familial acro- megaly and lead an international consortium demonstrating linkage to chromosome 11q13. Following the identification of AIP mutations, he and his collaborators helped elucidate the role of mutated AIP in the pathogenesis of GH-secreting tumors. He had also provided important information on the pathogenesis of prolactinomas and the pathogenesis of the hyperprolactinemia that occurred in patients with renal fail- ure. Larry’s contributions to clinical endocrinology were Our dear friend and colleague, Dr. Lawrence Frohman, not limited to pituitary regulation; he was one of the earli- passed away on March 4, 2018, at the age of 83, just 2 weeks est clinicians to document the relatively high incidence of before he was to receive the Outstanding Leadership http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pituitary Springer Journals

In Memoriam: Lawrence A. Frohman, M.D. January 26, 1935–March 4, 2018

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Diabetes; Human Physiology
ISSN
1386-341X
eISSN
1573-7403
D.O.I.
10.1007/s11102-018-0896-0
Publisher site
See Article on Publisher Site

Abstract

Pituitary https://doi.org/10.1007/s11102-018-0896-0 In Memoriam: Lawrence A. Frohman, M.D. January 26, 1935–March 4, 1 2 Seymour Reichlin  · Mark E. Molitch © Springer Science+Business Media, LLC, part of Springer Nature 2018 hormone (GH). He provided important early information regarding the hypothalamic regulation of GH secretion. Later, he identified and partially purified a GH releasing hormone (GHRH) from pancreatic and lung tumors, which eventually led to isolation and sequencing of the hormone. He published extensively on GHRH gene expression, secre- tion, and action. Larry also initiated studies in familial acro- megaly and lead an international consortium demonstrating linkage to chromosome 11q13. Following the identification of AIP mutations, he and his collaborators helped elucidate the role of mutated AIP in the pathogenesis of GH-secreting tumors. He had also provided important information on the pathogenesis of prolactinomas and the pathogenesis of the hyperprolactinemia that occurred in patients with renal fail- ure. Larry’s contributions to clinical endocrinology were Our dear friend and colleague, Dr. Lawrence Frohman, not limited to pituitary regulation; he was one of the earli- passed away on March 4, 2018, at the age of 83, just 2 weeks est clinicians to document the relatively high incidence of before he was to receive the Outstanding Leadership

Journal

PituitarySpringer Journals

Published: May 28, 2018

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