Pituitary (2018) 21:559–560 https://doi.org/10.1007/s11102-018-0896-0 In Memoriam: Lawrence A. Frohman, M.D. January 26, 1935–March 4, 1 2 Seymour Reichlin · Mark E. Molitch Published online: 28 May 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 hormone (GH). He provided important early information regarding the hypothalamic regulation of GH secretion. Later, he identified and partially purified a GH releasing hormone (GHRH) from pancreatic and lung tumors, which eventually led to isolation and sequencing of the hormone. He published extensively on GHRH gene expression, secre- tion, and action. Larry also initiated studies in familial acro- megaly and lead an international consortium demonstrating linkage to chromosome 11q13. Following the identification of AIP mutations, he and his collaborators helped elucidate the role of mutated AIP in the pathogenesis of GH-secreting tumors. He had also provided important information on the pathogenesis of prolactinomas and the pathogenesis of the hyperprolactinemia that occurred in patients with renal fail- ure. Larry’s contributions to clinical endocrinology were Our dear friend and colleague, Dr. Lawrence Frohman, not limited to pituitary regulation; he was one of the earli- passed away on March 4, 2018, at the age of 83, just 2 weeks est clinicians to document the relatively high incidence of before
Pituitary – Springer Journals
Published: May 28, 2018
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