Eur J Nutr (2018) 57:279–295 https://doi.org/10.1007/s00394-016-1317-7 ORIGINAL CONTRIBUTION Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high‑fat diet‑fed C57BL/6J mice 1 1 1 1 Mahalingam Balakumar · Durai Prabhu · Chandrakumar Sathishkumar · Paramasivam Prabu · 2 1 1 1 2 Namita Rokana · Ramesh Kumar · Srividhya Raghavan · Avinash Soundarajan · Sunita Grover · 2 1 1 Virender Kumar Batish · Viswanathan Mohan · Muthuswamy Balasubramanyam Received: 3 May 2016 / Accepted: 28 September 2016 / Published online: 18 October 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract was measured by intestinal permeability test. Transcrip- Purpose Diabetes and obesity are characterized by glu- tional levels of tight junction proteins (TJPs) were probed cose intolerance, fat deposition, inflammation, and dyslip - in small intestinal tissues while inflammatory signals and idemia. Recent reports postulated that distinct gut micro- other pathway specific genes were profiled in liver, visceral biota alterations were observed in obese/diabetic subjects adipose tissue, and skeletal muscle. and modulating gut microbiota beneficially through spe - Results Mice fed with HFD became insulin resistant, glu- cific probiotics could be a potential therapeutic option for cose intolerant, hyperglycemic, and dyslipidemic. Dia- type 2
European Journal of Nutrition – Springer Journals
Published: Oct 18, 2016
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