J Cancer Res Clin Oncol (2017) 143:1701–1712 DOI 10.1007/s00432-017-2428-0 ORIGINAL ARTICLE – CANCER RESEARCH Improved systemic treatment for early breast cancer improves cure rates, modifies metastatic pattern and shortens post‑metastatic survival: 35‑year results from the Munich Cancer Registry 1 1 2 3 4 5 6 Dieter Hölzel · Renate Eckel · Ingo Bauerfeind · Bernd Baier · Thomas Beck · Michael Braun · Johannes Ettl · 5 6 7 8 3 9 Ulrich Hamann · Marion Kiechle · Sven Mahner · Christian Schindlbeck · Johann de Waal · Nadia Harbeck · Jutta Engel Received: 12 April 2017 / Accepted: 13 April 2017 / Published online: 20 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract of liver and CNS METs has more than doubled, the rate of Purpose Systemic therapies (ATHs) in early breast cancer lung METs remains stable, and the rate of bone METs has have improved the survival of breast cancer (BC) patients been reduced by approximately 50%. MFS has been pro- in recent decades. The magnitude of the changes in overall, longed with a hazard ratio 0.75 (P < 0.0001), but PMS has metastasis-free (MFS) and post-metastatic (PMS) survival declined (hazard ratio 1.36; P < 0.0001); however,
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 20, 2017
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