Improved Synthesis of Dbibb as a New Anti-Radiation Agent
Improved Synthesis of Dbibb as a New Anti-Radiation Agent
Yang, Hong-Peng; Zhang, Shou-Guo; Wang, Gang; Wen, Xiao-Xue; Sun, Yun-Bo; Liu, Shu-Chen; Peng, Tao; Wang, Lin
2018-06-07 00:00:00
An excellent candidate in the fight against damage caused by nuclear radiation is 2-[4-(1,3-dioxo-1H,3Hbenzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB), a lipid agonist of lysophospholipid acid receptor 2. In this study, a novel method that synthesizes DBIBB was developed. In this method, saccharin was replaced singly by 1,4-dibromobutane, reacted with 1,8-naphthalimide, hydrolyzed by sodium hydroxide, and finally acidified by hydrochloric acid to obtain DBIBB. The new synthesis route was shorter, milder, and simpler than previously reported approaches. The method also produced higher total yield than that of existing ones. Thus, it is applicable to the large-scale synthesis of DBIBB.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngChemistry of Natural CompoundsSpringer Journalshttp://www.deepdyve.com/lp/springer-journals/improved-synthesis-of-dbibb-as-a-new-anti-radiation-agent-JgSDdn952U
Improved Synthesis of Dbibb as a New Anti-Radiation Agent
An excellent candidate in the fight against damage caused by nuclear radiation is 2-[4-(1,3-dioxo-1H,3Hbenzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB), a lipid agonist of lysophospholipid acid receptor 2. In this study, a novel method that synthesizes DBIBB was developed. In this method, saccharin was replaced singly by 1,4-dibromobutane, reacted with 1,8-naphthalimide, hydrolyzed by sodium hydroxide, and finally acidified by hydrochloric acid to obtain DBIBB. The new synthesis route was shorter, milder, and simpler than previously reported approaches. The method also produced higher total yield than that of existing ones. Thus, it is applicable to the large-scale synthesis of DBIBB.
Journal
Chemistry of Natural Compounds
– Springer Journals
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