Imprinting evolution and human health

Imprinting evolution and human health Genomic imprinting results in parent-of-origin-dependent, monoallelic expression of genes. The functional haploid state of these genes has far-reaching consequences. Not only has imprinting been implicated in accelerating mammalian speciation, there is growing evidence that it is also involved in the pathogenesis of several human conditions, particularly cancer and neurological disorders. Epigenetic regulatory mechanisms govern the parental allele-specific silencing of imprinted genes, and many theories have attempted to explain the driving force for the evolution of this unique form of gene control. This review discusses the evolution of imprinting in Therian mammals, and the importance of imprinted genes in human health and disease. Mammalian Genome Springer Journals

Imprinting evolution and human health

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Copyright © 2009 by Springer Science+Business Media, LLC
Life Sciences; Zoology ; Anatomy ; Cell Biology
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