Introduction Impaired skeletal muscle oxygenation potentially contributes to reduced exercise capacity in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients during early recovery and may explain altered hemoglo- bin responses to exercise following allo-HSCT. We investigated whether skeletal muscle oxygenation parameters and hemoglobin parameters in the tibialis anterior decreased following allo-HSCT, and whether these results were associ- ated with declines in exercise capacity. Methods We used near-infrared spectroscopy during and following a repeated isometric contraction task at 50% of maximal voluntary contraction in 18 patients before and after allo-HSCT. Results The rate of decrease in the muscle oxy-hemoglobin saturation (SmO ; an index of skeletal muscle oxygenation) was significantly lower after allo-HSCT (P < 0.01). In contrast, total hemoglobin (an index of hemoglobin) was not different after allo-HSCT. Furthermore, SmO during and following exercise was associated with exercise capacity (r =0.648; P = 0.004 vs. r = 0.632; P =0.005). Conclusion The results of this study reveal that although the peripheral hemoglobin response was not altered by allo-HSCT, skeletal muscle oxygenation was decreased following allo-HSCT. Furthermore, the decrease in skeletal muscle oxygenation was associated with a reduction in exercise capacity. . . Keywords Allogeneic hematopoietic stem cell transplantation Near infrared
Supportive Care in Cancer – Springer Journals
Published: Jan 25, 2018
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