Impaired skeletal muscle oxygenation following allogeneic
hematopoietic stem cell transplantation is associated
with exercise capacity
Received: 9 July 2017 / Accepted: 28 December 2017 / Published online: 25 January 2018
Springer-Verlag GmbH Germany, part of Springer Nature 2018
Introduction Impaired skeletal muscle oxygenation potentially contributes to reduced exercise capacity in allogeneic
hematopoietic stem cell transplantation (allo-HSCT) patients during early recovery and may explain altered hemoglo-
bin responses to exercise following allo-HSCT. We investigated whether skeletal muscle oxygenation parameters and
hemoglobin parameters in the tibialis anterior decreased following allo-HSCT, and whether these results were associ-
ated with declines in exercise capacity.
Methods We used near-infrared spectroscopy during and following a repeated isometric contraction task at 50% of maximal
voluntary contraction in 18 patients before and after allo-HSCT.
Results The rate of decrease in the muscle oxy-hemoglobin saturation (SmO
; an index of skeletal muscle oxygenation) was
significantly lower after allo-HSCT (P < 0.01). In contrast, total hemoglobin (an index of hemoglobin) was not different after
allo-HSCT. Furthermore, SmO
during and following exercise was associated with exercise capacity (r =0.648;P = 0.004 vs. r =
0.632; P =0.005).
Conclusion The results of this study reveal that although the peripheral hemoglobin response was not altered by allo-HSCT,
skeletal muscle oxygenation was decreased following allo-HSCT. Furthermore, the decrease in skeletal muscle oxygenation was
associated with a reduction in exercise capacity.
Keywords Allogeneic hematopoietic stem cell transplantation
Near infrared spectroscopy (NIRS)
* Tatsushi Wakasugi
Department of Rehabilitation, Hyogo College of Medicine Hospital,
Institute for Human Movement and Medical Sciences, Niigata
University of Health and Welfare, Niigata, Japan
Department of Rehabilitation Medicine, Hyogo College of Medicine,
Division of Haematology, Department of Internal Medicine, Hyogo
College of Medicine, Nishinomiya, Japan
Supportive Care in Cancer (2018) 26:2149–2160