Impact of Various Prognostic Factors on Overall Survival, Disease-Free Survival and Patterns of Failure in Carcinoma Cervix: A Tertiary Care Centre Experience from South India

Impact of Various Prognostic Factors on Overall Survival, Disease-Free Survival and Patterns of... Purpose As per GLOBACON 2012, the incidence of cervical cancer is 22.9% with a mortality rate of 54.9% (http:// globocan.iarc.fr, 2010). As the disease affects relatively younger population, high fatality rate impacts family and society in a disastrous way. Cervical carcinoma has a relatively poor prognosis due to advanced stage at presentation. We retrospectively analysed the treated cases of carcinoma cervix to know the impact of various prognostic factors on survival and patterns of failure in our hospital. Methods All cases treated from 2010 to 2015 (total 920 pts) who completed curative treatment in a tertiary care hospital were analysed to evaluate overall survival, disease-free survival, factors impacting survival, patterns of failure, factors affecting failure, mortality, and treatment-related toxicity. OS and DFS were calculated with Kaplan–Meier method, and log-rank test was used to identify the difference between groups. Failure factors were correlated with logistic regression, and toxicity was expressed in percentage. Results Univariate and multivariate analyses were performed. Pre treatment staging, lymphadenopathy, imaging used for diagnosis, hemoglobin levels extent of vagina involved and during treatment usage of concurrent chemotherapy, dose of radiation used, development of neutropenia and aftercompletion of treatment type of response had shown significant impact on DFS http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Gynecologic Oncology Springer Journals

Impact of Various Prognostic Factors on Overall Survival, Disease-Free Survival and Patterns of Failure in Carcinoma Cervix: A Tertiary Care Centre Experience from South India

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Publisher
Springer India
Copyright
Copyright © 2018 by Association of Gynecologic Oncologists of India
Subject
Medicine & Public Health; Oncology; Surgical Oncology
ISSN
2363-8397
eISSN
2363-8400
D.O.I.
10.1007/s40944-018-0179-8
Publisher site
See Article on Publisher Site

Abstract

Purpose As per GLOBACON 2012, the incidence of cervical cancer is 22.9% with a mortality rate of 54.9% (http:// globocan.iarc.fr, 2010). As the disease affects relatively younger population, high fatality rate impacts family and society in a disastrous way. Cervical carcinoma has a relatively poor prognosis due to advanced stage at presentation. We retrospectively analysed the treated cases of carcinoma cervix to know the impact of various prognostic factors on survival and patterns of failure in our hospital. Methods All cases treated from 2010 to 2015 (total 920 pts) who completed curative treatment in a tertiary care hospital were analysed to evaluate overall survival, disease-free survival, factors impacting survival, patterns of failure, factors affecting failure, mortality, and treatment-related toxicity. OS and DFS were calculated with Kaplan–Meier method, and log-rank test was used to identify the difference between groups. Failure factors were correlated with logistic regression, and toxicity was expressed in percentage. Results Univariate and multivariate analyses were performed. Pre treatment staging, lymphadenopathy, imaging used for diagnosis, hemoglobin levels extent of vagina involved and during treatment usage of concurrent chemotherapy, dose of radiation used, development of neutropenia and aftercompletion of treatment type of response had shown significant impact on DFS

Journal

Indian Journal of Gynecologic OncologySpringer Journals

Published: Jan 31, 2018

References

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