J Cancer Res Clin Oncol (2017) 143:1745–1756 DOI 10.1007/s00432-017-2431-5 ORIGINAL ARTICLE – CANCER RESEARCH Impact of intra‑tumoral IL17A and IL32 gene expression on T‑cell responses and lymph node status in breast cancer patients 1 1,5 1 1 Shreyas Bhat · Nilesh Gardi · Sujata Hake · Nirupama Kotian · 1 2 3,5 4,5 Sharada Sawant · Sadhana Kannan · Vani Parmar · Sangeeta Desai · 1,5 1,5 Amit Dutt · Narendra N. Joshi Received: 5 February 2016 / Accepted: 20 April 2017 / Published online: 3 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract in the latter group (26.2 vs 7.1-fold, p < 0.01). ER-negative Purpose Pro-inflammatory cytokines such as Interleukin- tumors also showed higher expression of IL32 as opposed 17A (IL17A) and Interleukin-32 (IL32), known to enhance to ER-positive tumors (8.7 vs 2.5-fold, p < 0.01). Expres- natural killer and T cell responses, are also elevated in sion of both IL17A and IL32 genes positively correlated human malignancies and linked to poor clinical outcomes. with CCL5, GNLY, TBX21, IL21 and IL23 transcript lev- To address this paradox, we evaluated relation between els (p < 0.01). Amongst ER-positive tumors, higher IL32 IL17A and IL32 expression and other inflammation- and
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: May 3, 2017
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