Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder

Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder J Cancer Res Clin Oncol (2017) 143:1659–1670 DOI 10.1007/s00432-017-2404-8 ORIGINAL ARTICLE – CANCER RESEARCH Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder 1,2 2 3 1 Jochen Hess  · Patrick Stelmach  · Andreas Eisenhardt  · Herbert Rübben  · 4 4 2 Henning Reis  · Kurt Werner Schmid  · Hagen Sjard Bachmann   Received: 26 December 2016 / Accepted: 24 March 2017 / Published online: 17 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract determine the putative impact of the three polymorphisms Purpose To evaluate the impact of three BCL2 single- on outcome. nucleotide polymorphisms, i.e., c.−938C>A (rs2279115), Results c.−938C>A and c.21G>A, but not c.*2203A>G, c.21G>A (rs1801018), and c.*2203A>G (rs4987853) on are in strong linkage disequilibrium (D′ 0.96). We found a survival in patients with transitional cell carcinoma of the significant association between c.−938C>A and relapse- bladder. free survival (p = 0.024) with an allele dose effect. In the Methods We analyzed 179 patients who underwent sur- same way, c.21G>A had a significant impact on both gical treatment for bladder cancer at the Clinic of Urol- relapse-free survival (p = 0.009) and progression-free sur- ogy, University Hospital Essen, Germany. Genomic DNA vival (p = 0.012), as well as a pronounced allele dose effect. was extracted and genotyped for the Journal of Cancer Research and Clinical Oncology Springer Journals

Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
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