J Cancer Res Clin Oncol (2017) 143:1659–1670 DOI 10.1007/s00432-017-2404-8 ORIGINAL ARTICLE – CANCER RESEARCH Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder 1,2 2 3 1 Jochen Hess · Patrick Stelmach · Andreas Eisenhardt · Herbert Rübben · 4 4 2 Henning Reis · Kurt Werner Schmid · Hagen Sjard Bachmann Received: 26 December 2016 / Accepted: 24 March 2017 / Published online: 17 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract determine the putative impact of the three polymorphisms Purpose To evaluate the impact of three BCL2 single- on outcome. nucleotide polymorphisms, i.e., c.−938C>A (rs2279115), Results c.−938C>A and c.21G>A, but not c.*2203A>G, c.21G>A (rs1801018), and c.*2203A>G (rs4987853) on are in strong linkage disequilibrium (D′ 0.96). We found a survival in patients with transitional cell carcinoma of the significant association between c.−938C>A and relapse- bladder. free survival (p = 0.024) with an allele dose effect. In the Methods We analyzed 179 patients who underwent sur- same way, c.21G>A had a significant impact on both gical treatment for bladder cancer at the Clinic of Urol- relapse-free survival (p = 0.009) and progression-free sur- ogy, University Hospital Essen, Germany. Genomic DNA vival (p = 0.012), as well as a pronounced allele dose effect. was extracted and genotyped for the
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: Apr 17, 2017
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