Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder

Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder J Cancer Res Clin Oncol (2017) 143:1659–1670 DOI 10.1007/s00432-017-2404-8 ORIGINAL ARTICLE – CANCER RESEARCH Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder 1,2 2 3 1 Jochen Hess  · Patrick Stelmach  · Andreas Eisenhardt  · Herbert Rübben  · 4 4 2 Henning Reis  · Kurt Werner Schmid  · Hagen Sjard Bachmann   Received: 26 December 2016 / Accepted: 24 March 2017 / Published online: 17 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract determine the putative impact of the three polymorphisms Purpose To evaluate the impact of three BCL2 single- on outcome. nucleotide polymorphisms, i.e., c.−938C>A (rs2279115), Results c.−938C>A and c.21G>A, but not c.*2203A>G, c.21G>A (rs1801018), and c.*2203A>G (rs4987853) on are in strong linkage disequilibrium (D′ 0.96). We found a survival in patients with transitional cell carcinoma of the significant association between c.−938C>A and relapse- bladder. free survival (p = 0.024) with an allele dose effect. In the Methods We analyzed 179 patients who underwent sur- same way, c.21G>A had a significant impact on both gical treatment for bladder cancer at the Clinic of Urol- relapse-free survival (p = 0.009) and progression-free sur- ogy, University Hospital Essen, Germany. Genomic DNA vival (p = 0.012), as well as a pronounced allele dose effect. was extracted and genotyped for the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals

Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
ISSN
0171-5216
eISSN
1432-1335
D.O.I.
10.1007/s00432-017-2404-8
Publisher site
See Article on Publisher Site

Abstract

J Cancer Res Clin Oncol (2017) 143:1659–1670 DOI 10.1007/s00432-017-2404-8 ORIGINAL ARTICLE – CANCER RESEARCH Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder 1,2 2 3 1 Jochen Hess  · Patrick Stelmach  · Andreas Eisenhardt  · Herbert Rübben  · 4 4 2 Henning Reis  · Kurt Werner Schmid  · Hagen Sjard Bachmann   Received: 26 December 2016 / Accepted: 24 March 2017 / Published online: 17 April 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract determine the putative impact of the three polymorphisms Purpose To evaluate the impact of three BCL2 single- on outcome. nucleotide polymorphisms, i.e., c.−938C>A (rs2279115), Results c.−938C>A and c.21G>A, but not c.*2203A>G, c.21G>A (rs1801018), and c.*2203A>G (rs4987853) on are in strong linkage disequilibrium (D′ 0.96). We found a survival in patients with transitional cell carcinoma of the significant association between c.−938C>A and relapse- bladder. free survival (p = 0.024) with an allele dose effect. In the Methods We analyzed 179 patients who underwent sur- same way, c.21G>A had a significant impact on both gical treatment for bladder cancer at the Clinic of Urol- relapse-free survival (p = 0.009) and progression-free sur- ogy, University Hospital Essen, Germany. Genomic DNA vival (p = 0.012), as well as a pronounced allele dose effect. was extracted and genotyped for the

Journal

Journal of Cancer Research and Clinical OncologySpringer Journals

Published: Apr 17, 2017

References

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