Impact of a novel precursor on FK506 production and key gene transcription in Streptomyces tsukubaensis No. 9993

Impact of a novel precursor on FK506 production and key gene transcription in Streptomyces... FK506, a widely used immunosuppressant, is produced by industrial fermentation using Streptomyces tsukubaensis. In this study, a novel precursor, salicyl alcohol, was added and provided significant improvement in FK506 production. Furthermore, differences of the expression of the structural genes between the two media were also investigated. The results showed that the expression of key genes in enriched medium was much higher than that in the control. Compared with the non-enriched medium, the enriched medium caused 52.25-% enhancement of FK506 production. Salicyl alcohol could play a crucial role in the transcription of FK506 structural genes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Impact of a novel precursor on FK506 production and key gene transcription in Streptomyces tsukubaensis No. 9993

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-015-2215-y
Publisher site
See Article on Publisher Site

Abstract

FK506, a widely used immunosuppressant, is produced by industrial fermentation using Streptomyces tsukubaensis. In this study, a novel precursor, salicyl alcohol, was added and provided significant improvement in FK506 production. Furthermore, differences of the expression of the structural genes between the two media were also investigated. The results showed that the expression of key genes in enriched medium was much higher than that in the control. Compared with the non-enriched medium, the enriched medium caused 52.25-% enhancement of FK506 production. Salicyl alcohol could play a crucial role in the transcription of FK506 structural genes.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Sep 14, 2015

References

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