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Immunosuppressants

Immunosuppressants Reactions 1704, p197 - 2 Jun 2018 Colonic perforation secondary to cytomegaloviral colitis and cytomegaloviral infection: case report A 69-year-old man developed colonic perforation secondary to cytomegaloviral colitis and cytomegaloviral infection following treatment with cyclophosphamide, methotrexate, methylprednisolone and prednisone [not all routes stated]. The man, who was diagnosed with upper airways-limited granulomatosis with polyangiitis in 2009 and treated with prednisone 5 mg/day and methotrexate 20 mg/week, was admitted to the hospital due to acute kidney injury. On admission, his laboratory examinations were found significant for increased creatinine level, mild anaemia, proteinurea, haematuria and an elevated antineutrophil cytoplasmic antibody (PR3-ANCA) titre. His renal biopsy showed rapidly progressive necrotising granulomatous glomerulonephritis. As a result, he received IV pulse-dose methylprednisolone 1 g/day for three days, followed by oral prednisone 1 mg/kg, followed by cyclophosphamide pulse 1g (to be repeated once a month for six months) as induction remission therapy. His systemic symptoms resolved; however, renal function did not improve. He was discharged with prednisone 50 mg/day with gradual tapering and also received cotrimoxazole [trimethoprim- sulfamethoxazole] for prophylaxis of Pneumocystis jirovecii. On day 40, he was admitted to receive second pulse of cyclophosphamide as planned. Before the admission, he reported a 3 day http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Immunosuppressants

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Immunosuppressants

Abstract

Reactions 1704, p197 - 2 Jun 2018 Colonic perforation secondary to cytomegaloviral colitis and cytomegaloviral infection: case report A 69-year-old man developed colonic perforation secondary to cytomegaloviral colitis and cytomegaloviral infection following treatment with cyclophosphamide, methotrexate, methylprednisolone and prednisone [not all routes stated]. The man, who was diagnosed with upper airways-limited granulomatosis with polyangiitis in 2009 and treated with prednisone 5 mg/day...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46840-4
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p197 - 2 Jun 2018 Colonic perforation secondary to cytomegaloviral colitis and cytomegaloviral infection: case report A 69-year-old man developed colonic perforation secondary to cytomegaloviral colitis and cytomegaloviral infection following treatment with cyclophosphamide, methotrexate, methylprednisolone and prednisone [not all routes stated]. The man, who was diagnosed with upper airways-limited granulomatosis with polyangiitis in 2009 and treated with prednisone 5 mg/day and methotrexate 20 mg/week, was admitted to the hospital due to acute kidney injury. On admission, his laboratory examinations were found significant for increased creatinine level, mild anaemia, proteinurea, haematuria and an elevated antineutrophil cytoplasmic antibody (PR3-ANCA) titre. His renal biopsy showed rapidly progressive necrotising granulomatous glomerulonephritis. As a result, he received IV pulse-dose methylprednisolone 1 g/day for three days, followed by oral prednisone 1 mg/kg, followed by cyclophosphamide pulse 1g (to be repeated once a month for six months) as induction remission therapy. His systemic symptoms resolved; however, renal function did not improve. He was discharged with prednisone 50 mg/day with gradual tapering and also received cotrimoxazole [trimethoprim- sulfamethoxazole] for prophylaxis of Pneumocystis jirovecii. On day 40, he was admitted to receive second pulse of cyclophosphamide as planned. Before the admission, he reported a 3 day

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

References

  • Colonic perforation due to severe cytomegalovirus disease in granulomatosis with polyangiitis after immunosuppression.
    Soriano, A