Immunosuppressants Reactions 1680, p173 - 2 Dec 2017 Upper respiratory tract infection, clostridium- difficile enteritis and fatal septic shock: 4 case reports In a retrospective analysis of the immunoadsorption treatments (without immune-globulin), 4 adult patients (02 men and 02 women) aged 31 60 years were described, who developed upper respiratory tract infection, clostridium- difficile enteritis or fatal septic shock following treatment with carboplatin, etoposide, mycophenolate mofetil, rituximab or prednisolone [routes and time to reactions onsets not stated; not all dosages and outcomes stated]. A 58-year-old man developed upper respiratory tract infection during treatment with prednisolone and rituximab. The man, who had membranous glomerulonephritis, was receiving treatment with prednisolone 7.5 mg/day and rituximab 100mg weekly. Subsequently, he developed an afebrile mild upper respiratory tract infection without fever. A 60-year-old woman developed clostridium-difficile enteritis following treatment with etoposide and carboplatin. The woman, who had paraneoplastic cerebellitis because of a bronchial carcinoma, was receiving treatment with etoposide and carboplatin. Subsequently, she developed clostridium- difficile enteritis. A 56-year-old man developed clostridium-difficile enteritis following treatment with rituximab, mycophenolate mofetil and prednisolone. The man, who had bullous pemphigoid, was receiving treatment with mycophenolate mofetil 3 g/day, prednisolone 50 mg/day and rituximab 1000mg. Subsequently, he developed clostridium-difficile enteritis. A 31-year-old woman developed fatal septic shock following treatment with prednisolone. The woman, who had a severe meningoencephalopathy of unknown origin, was treated with a high dose prednisolone. After 2.5 weeks of the therapy, she died due to septic shock. Author comment: "The majority of our patients (though including only one with lupus erythematosus) also received immunosuppressants (steroids, cyclophosphamide, cyclosporine, carboplatin, mycophenolat mofetil, etoposide, monoclonal antibodies)". "We showed that even without regular substitution of [intravenous immunoglobulins] after intensive [immunoadsorption] treatment, the rate of infections directly linked with [immunoadsorption] is low." "Only 4 patients had infections (7.7%)." Tselmin S, et al. Low rate of infectious complications following immunoadsorption therapy without regular substitution of intravenous immunoglobulins. Atherosclerosis Supplements 30: 278-282, Nov 2017. Available from: URL: http:// - Germany 803285009 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
1 page

Loading next page...
1 Page
Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial