BioDrugs (2017) 31:299–316 DOI 10.1007/s40259-017-0231-8 SYSTEMATIC REVIEW Immunogenicity of Biologics in Chronic Inﬂammatory Diseases: A Systematic Review 1 2 3 4 • • • • Vibeke Strand Alejandro Balsa Jamal Al-Saleh Leonor Barile-Fabris 5 6 7 8 • • • • Takahiko Horiuchi Tsutomu Takeuchi Sadiq Lula Charles Hawes 8 9 Blerina Kola Lisa Marshall Published online: 13 June 2017 The Author(s) 2017. This article is an open access publication Abstract (AS), non-radiographic axial spondyloarthritis (nr-axSpA), Objectives A systematic review was conducted to explore psoriasis (Ps), Crohn’s disease, and ulcerative colitis. the immunogenicity of biologic agents across inﬂammatory Results Of [21,000 screened publications, 443 were diseases and its potential impact on efﬁcacy/safety. included. Anti-drug antibody (ADAb) rates varied widely Methods Literature searches were conducted through among biologics across diseases (and are not directly November 2016 to identify controlled and observational comparable because of immunoassay heterogeneity); the studies of biologics/biosimilars administered for treatment highest overall rates were reported with inﬂiximab of rheumatoid arthritis (RA), psoriatic arthritis (PsA), (0–83%), adalimumab (0–54%), and inﬂiximab biosimilar juvenile idiopathic arthritis (JIA), ankylosing spondylitis CT-P13 (21–52%), and the lowest with secukinumab (0–1%), ustekinumab (1–11%), etanercept (0–13%), and golimumab (0–19%). Most ADAbs were neutralizing, Electronic supplementary
BioDrugs – Springer Journals
Published: Jun 13, 2017
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