Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer

Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine... Considerable evidence indicates a negative correlation between the prevalence of some parasitic infections and cancer and their interference with tumor growth. Therefore, parasitic antigens seem to be promising candidates for cancer immunotherapy. In this study, the therapeutic efficacy of autoclaved Schistosoma mansoni and Trichinella spiralis antigens against a colon cancer murine model was investigated. Both antigens showed immunomodulatory potential, as evidenced by a significant decrease in serum IL-17, a significant increase in serum IL-10, and the percentage of splenic CD4+T-cells and intestinal FoxP3+ Treg cells. However, treatment with S. mansoni antigen yielded protection against the deleterious effect of DMH-induced colon carcinogenesis only, with a significant decrease in the average lesion size and number of neoplasias per mouse. For the first time, we report an inhibitory effect of S. mansoni antigen on the progression of chemically induced colon carcinogenesis, but the exact mechanism has yet to be clarified. This anti-tumor strategy could introduce a new era of medicine in which a generation of anticancer vaccines of parasitic origin would boost the therapy for incurable cancers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Investigational New Drugs Springer Journals

Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Oncology; Pharmacology/Toxicology
ISSN
0167-6997
eISSN
1573-0646
DOI
10.1007/s10637-018-0609-6
Publisher site
See Article on Publisher Site

Abstract

Considerable evidence indicates a negative correlation between the prevalence of some parasitic infections and cancer and their interference with tumor growth. Therefore, parasitic antigens seem to be promising candidates for cancer immunotherapy. In this study, the therapeutic efficacy of autoclaved Schistosoma mansoni and Trichinella spiralis antigens against a colon cancer murine model was investigated. Both antigens showed immunomodulatory potential, as evidenced by a significant decrease in serum IL-17, a significant increase in serum IL-10, and the percentage of splenic CD4+T-cells and intestinal FoxP3+ Treg cells. However, treatment with S. mansoni antigen yielded protection against the deleterious effect of DMH-induced colon carcinogenesis only, with a significant decrease in the average lesion size and number of neoplasias per mouse. For the first time, we report an inhibitory effect of S. mansoni antigen on the progression of chemically induced colon carcinogenesis, but the exact mechanism has yet to be clarified. This anti-tumor strategy could introduce a new era of medicine in which a generation of anticancer vaccines of parasitic origin would boost the therapy for incurable cancers.

Journal

Investigational New Drugs – Springer Journals

Published: May 28, 2018

References

  • Cancer vaccines: between the idea and the reality
    Finn, JO
  • Cancer immunotherapy comes of age
    Mellman, I; Coukos, G; Dranoff, G
  • Parasites and cancers: parasite antigens as possible targets for cancer immunotherapy
    Darani, HY; Yousefi, M
  • Echinococcus against cancer: why not?
    Akgül, H; Tez, M; Ünal, AE; Keşkek, M; Sayek, I; Özçelik, T
  • Trichinella spiralis infection reduces tumor growth and metastasis of B16-F10 melanoma cells
    Kang, Y; Jo, J; Cho, M; Yu, H; Leem, S; Song, KS
  • Evaluation of Toxoplasma gondii as a live vaccine vector in susceptible and resistant hosts
    Zou, J; Huang, XX; Yin, GW; Ding, Y; Liu, XY; Wang, H; Chen, QJ; Suo, X
  • Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers
    Ubillos, L; Freire, T; Berriel, E; Chiribao, ML; Chiale, C; Festari, MF; Medeiros, A; Mazal, D; Rondán, M; Bollati-Fogolín, M; Rabinovich, GA; Robello, C; Osinaga, E
  • Autoclaved cercarial vaccine against schistosomiasis: ultrastructural and biochemical analysis
    Eissa, MM; Allam, SR; El-Mahdi, AR; El-Azzouni, MZ
  • Initial characterization of an autoclaved toxoplasma vaccine in mice
    Eissa, MM; El-Azzouni, MZ; Mady, RF; Fathy, FM; Baddour, NM
  • Further studies on autoclaved cercarial vaccine against schistosomiasis safety, longevity and stability
    Eissa, MM; Allam, SR; El-Azzouni, MZ; Maged, HR; Dessouky, IS
  • Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines
    Hakomori, S
  • MUC1 and the MUCs: a family of human mucins with impact in cancer biology
    Baldus, SE; Engelmann, K; Hanisch, FG
  • Vaccination trial against experimental trichinosis using autoclaved Trichinella spiralis larva vaccine
    Eissa, MM; El-Azzouni, MZ; Bolous, LM
  • Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice
    Yang, X; Yang, Y; Wang, Y; Zhan, B; Gu, Y; Cheng, Y; Zhu, X
  • Experimental chemotherapy of schistosomiasis mansoni
    Pellegrino, J; Katz, N
  • Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment
    Pica-Mattoccia, L; Cioli, D
  • T. Spiralis induced by different Trichinella isolates
    Wasson, DL; Dougherky, DA; Dick, TA
  • Anti- arthritic activity of Schistosoma mansoni and Trichinella Spiralis derived-antigens in adjuvant arthritis in rats: role of FOXP3+ Treg cells
    Eissa, MM; Mostafa, DK; Ghazy, AA; El-azzouni, MZ; Boulos, LM; Younis, LK
  • Protein measurement with the Folin phenol reagent
    Lowry, OH; Rosebrough, NS; Fan, AL; Randall, RS
  • Induction of adenocarcinomas of the Colon in mice by weekly injections of 1,2-Dimethylhydrazine
    Thurnherr, N; Deschner, EE; Stonehill, EH; Lipkin, M
  • Schistosoma mansoni: anomalous immunogenic properties of a 27 kDa larval serine protease associated with protective immunity
    Darani, HY; Curtis, RH; McNeice, C; Price, HP; Sayers, JR; Doenhoff, MJ
  • Trichinella spiralis-A potential anti-tumor agent
    Wang, XL; Fu, BQ; Yang, SJ; Wu, XP; Cui, GZ; Liu, MF; Zhao, Y; Yu, YL; Liu, XY; Deng, HK; Chen, QJ; Liu, MY
  • Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice
    Deane, NG; Parker, MA; Aramandla, R; Diehl, L; Lee, WJ; Washington, MK; Nanney, LB; Shyr, Y; Beauchamp, RD
  • Expression of Foxp3 in colorectal Cancer but not in Treg cells correlates with disease progression in patients with colorectal Cancer
    Kim, M; Grimmig, T; Grimm, M; Lazariotou, M; Meier, E; Rosenwald, A; Tsaur, I; Blaheta, R; Heemann, U; Germer, CT; Waaga-Gasser, AM; Gasser, M
  • Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behaviour of human colorectal cancer
    Schimanski, CC; Schwald, S; Simiantonaki, N; Jayasinghe, C; Gönner, U; Wilsberg, V; Junginger, T; Berger, MR; Galle, PR; Moehler, M
  • Regulatory T cells in colorectal cancer: from biology to prognostic relevance
    Mougiakakos, D
  • Colorectal carcinoma associated with schistosomiasis: a possible causal relationship
    Salim, OE; Hamid, HK; Mekki, SO; Suleiman, SH; Ibrahim, SZ
  • Prognostic role of FOXP3+ regulatory T-cells infiltrating human carcinomas: the paradox of colorectal cancer
    Ladoire, S; Martin, F; Ghiringhelli, F
  • The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells
    Hesse, M; Piccirillo, CA; Belkaid, Y; Prufer, J; Mentink-Kane, M; Leusink, M; Cheever, AW; Shevach, EM; Wynn, TA
  • Schistosoma mansoni tegument (Smteg) induces IL-10 and modulates experimental airway inflammation
    Marinho, FV; Alves, CC; Souza, SC; Silva, CM; Cassali, GD; Oliveira, SC
  • Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions
    Amedei, A; Niccolai, E; Benagiano, M; Della Bella, C; Cianchi, F; Bechi, P; Taddei, A; Bencini, L; Farsi, M; Cappello, P; Prisco, D; Novelli, F; D’Elios, MM
  • Cd4+ cd25+ foxp3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer
    Clarke, SL; Betts, GJ; Plant, A; Wright, KL; El-Shanawany, TM; Harrop, R
  • Tumor-infiltrating t-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review
    Nosho, K; Baba, Y; Tanaka, N; Shima, K; Hayashi, M; Meyerhardt, JA; Giovannucci, E; Dranoff, G; Fuchs, CS; Ogino, S
  • Interleukin-17: a promoter in colorectal Cancer progression
    Wu, D; Wu, P; Huang, Q; Liu, Y; Ye, J; Huang, J
  • Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice
    Urban, JF; Katona, IM; Paul, WE; Finkelman, FD
  • TGF-β signalling alterations and susceptibility to colorectal cancer
    Xu, Y; Pasche, B
  • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favourable prognosis in ovarian cancer
    Sato, E; Olson, SH; Ahn, J; Bundy, B; Nishikawa, H; Qian, F; Jungbluth, AA; Frosina, D; Gnjatic, S; Ambrosone, C; Kepner, J; Odunsi, T; Ritter, G; Lele, S; Chen, YT; Ohtani, H; Old, LJ; Odunsi, K
  • Simple mucin-type cancer associated antigens are pre-cancerous biomarkers during 1,2-dimethylhydrazine-induced rat colon carcinogenesis
    Berriel, E; Hill, M; Barcia, JJ; Ubillos, L; Gonza’lez, M; Detjen, G
  • Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions
    Brockhausen, I
  • Thomsen-Friedenreich oncofetal antigen in Schistosoma mansoni: localization and immunogenicity in experimental mouse infection
    Thors, C; Jansson, B; Helin, H; Linder, E
  • Expression of a highly conserved oncofetal gene, TA1/E16, in human colon carcinoma and other primary cancers: homology to Schistosoma mansoni amino acid permease and Caenorhabditis elegans gene products
    Wolf, DA; Wang, S; Panzica, MA; Bassily, NH; Thompson, NL
  • Workshop on a detailed characterization of Trichinella spiralis antigens: a platform for future studies on antigens and antibodies to this parasite
    Ortega-Pierres, MG; Yepez-Mulia, L; Homan, W; Gamble, HR; Lim, PL; Takahashi, Y

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