Investigational New Drugs https://doi.org/10.1007/s10637-018-0609-6 PRECLINICAL STUDIES Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer 1 2 1 3 4 Maha M. Eissa & Cherine A. Ismail & Mervat Z. El-Azzouni & Amany A. Ghazy & Mona A. Hadi Received: 4 February 2018 /Accepted: 1 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Summary Considerable evidence indicates a negative correlation between the prevalence of some parasitic infections and cancer and their interference with tumor growth. Therefore, parasitic antigens seem to be promising candidates for cancer immunotherapy. In this study, the therapeutic efficacy of autoclaved Schistosoma mansoni and Trichinella spiralis antigens against a colon cancer murine model was investigated. Both antigens showed immunomodulatory potential, as evidenced by a significant decrease in serum IL-17, a significant increase in serum IL-10, and the percentage of + + splenic CD4 T-cells and intestinal FoxP3 Treg cells. However, treatment with S. mansoni antigen yielded protection against the deleterious effect of DMH-induced colon carcinogenesis only, with a significant decrease in the average lesion size and number of neoplasias per mouse. For the first time, we report an inhibitory effect of S. mansoni antigen on the
Investigational New Drugs – Springer Journals
Published: May 28, 2018
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