Immunity and immunopathology in early human life

Immunity and immunopathology in early human life Semin Immunopathol (2017) 39:575–576 INTRODUCTION 1 2 Tobias R. Kollmann & Arnaud Marchant Received: 9 October 2017 /Accepted: 9 October 2017 /Published online: 23 November 2017 Springer-Verlag GmbH Germany 2017 This special issue, BImmunocompetence of the Newborn^,is been achieved through the recognition that the fetal and new- focused on the induction and regulation of immune responses born immune system is not simply less responsive, but func- in early life, because recent studies of early life immune on- tionally different from that of an adult, and that these differ- togeny call into question the prevailing view of an immature ences reflect age-dependent differences in the demands [5, 6]. However, this new insight now begs to answer the question: If newborn immune system. Infectious disease cause nearly one third of all neonatal the fetus or newborn is capable of adult-like immune re- deaths; in addition, a large proportion of stillbirths are pre- sponses, why do they clinically suffer more readily from in- sumed to be related to an infectious insult of the maternal- fectious insults? This special edition explores one possible fetal dyad [1]. This harsh clinical reality of an increased risk answer: The fetus and newborn may suffer more Seminars in Immunopathology Springer Journals

Immunity and immunopathology in early human life

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag GmbH Germany
Biomedicine; Immunology; Internal Medicine
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