Immune Monitoring for CMV in Transplantation

Immune Monitoring for CMV in Transplantation Purpose of Review Immune monitoring to determine when and how the recovery of cytomegalovirus (CMV)-specific T-cells occurs post-transplantation may help clinicians to risk stratify individuals at risk of complications from CMV. We aimed to review all recent clinical studies using CMV immune monitoring in the pre- and post-transplant setting including the use of recently developed standardized assays (Quantiferon-CMV and the CMV ELISPOT) to better understand in whom, when, and how immune monitoring is best used. Recent Findings Pre-transplant assessment of CMV immunity in solid-organ transplant recipients where CMV seropositive recipients had undetectable cell-mediated responses despite past immunity has shown that they are at a much higher risk of developing CMV reactivation. Post-transplant CMV immune monitoring can guide (shorten or prolong) the duration of antiviral prophylaxis, identify recipients at risk of post-prophylaxis CMV disease, and predict recurrent CMV reactivation. Summary Thus, CMV immune monitoring, in addition to current clinical and DNA-based monitoring for CMV, has the potential to be incorporated into routine clinical care to better improve CMV management in both the stem and solid-organ transplant population. . . . . Keywords Cytomegalovirus Solid-organ transplantation Stem-cell transplantation CMV-specific immunity Immune . . monitoring Quantiferon-CMV ELISPOT Introduction decades [1]. However, significant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Infectious Disease Reports Springer Journals

Immune Monitoring for CMV in Transplantation

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Infectious Diseases
ISSN
1523-3847
eISSN
1534-3146
D.O.I.
10.1007/s11908-018-0610-4
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Immune monitoring to determine when and how the recovery of cytomegalovirus (CMV)-specific T-cells occurs post-transplantation may help clinicians to risk stratify individuals at risk of complications from CMV. We aimed to review all recent clinical studies using CMV immune monitoring in the pre- and post-transplant setting including the use of recently developed standardized assays (Quantiferon-CMV and the CMV ELISPOT) to better understand in whom, when, and how immune monitoring is best used. Recent Findings Pre-transplant assessment of CMV immunity in solid-organ transplant recipients where CMV seropositive recipients had undetectable cell-mediated responses despite past immunity has shown that they are at a much higher risk of developing CMV reactivation. Post-transplant CMV immune monitoring can guide (shorten or prolong) the duration of antiviral prophylaxis, identify recipients at risk of post-prophylaxis CMV disease, and predict recurrent CMV reactivation. Summary Thus, CMV immune monitoring, in addition to current clinical and DNA-based monitoring for CMV, has the potential to be incorporated into routine clinical care to better improve CMV management in both the stem and solid-organ transplant population. . . . . Keywords Cytomegalovirus Solid-organ transplantation Stem-cell transplantation CMV-specific immunity Immune . . monitoring Quantiferon-CMV ELISPOT Introduction decades [1]. However, significant

Journal

Current Infectious Disease ReportsSpringer Journals

Published: Mar 14, 2018

References

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