Access the full text.
Sign up today, get DeepDyve free for 14 days.
Yi Jiang, Jianwen Bai, Lunxian Tang, Pei Zhang, Jun Pu (2015)
Anti-CCL21 Antibody Attenuates Infarct Size and Improves Cardiac Remodeling After Myocardial InfarctionCellular Physiology and Biochemistry, 37
Wei Gao, Ye Xiong, Qiang Li, Hong Yang (2017)
Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano TherapeuticsFrontiers in Physiology, 8
Jiong-Wei Wang, M. Fontes, Xiaoyuan Wang, Suet Chong, E. Kessler, Ya-Nan Zhang, J. Haan, F. Arslan, S. Jager, L. Timmers, T. Veen, C. Lam, D. Kleijn (2017)
Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure OverloadScientific Reports, 7
T. Kitai, Jennifer Kirsop, W. Tang (2016)
Exploring the Microbiome in Heart FailureCurrent Heart Failure Reports, 13
T. Kubota, G. Bounoutas, M. Miyagishima, T. Kadokami, V. Sanders, C. Bruton, P. Robbins, C. McTiernan, A. Feldman (2000)
Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy.Circulation, 101 21
E. Stephenson, K. Savvatis, S. Mohiddin, F. Marelli-Berg (2017)
T‐cell immunity in myocardial inflammation: pathogenic role and therapeutic manipulationBritish Journal of Pharmacology, 174
Hongxia Tang, Yucheng Zhong, Yun-shan Zhu, Fangwen Zhao, Xiaoxue Cui, Zhaohui Wang (2010)
Low responder T cell susceptibility to the suppressive function of regulatory T cells in patients with dilated cardiomyopathyHeart, 96
A. Haberland, M. Holtzhauer, A. Schlichtiger, S. Bartel, I. Schimke, Johannes Müller, M. Dandel, P. Luppa, G. Wallukat (2016)
Aptamer BC 007 - A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors.European journal of pharmacology, 789
V. Topkara, Kari Chambers, Kai-Chien Yang, Huei‐Ping Tzeng, Sarah Evans, C. Weinheimer, A. Kovács, J. Robbins, P. Barger, D. Mann (2016)
Functional significance of the discordance between transcriptional profile and left ventricular structure/function during reverse remodeling.JCI insight, 1 4
D. Clark, M. Cleman, S. Pfau, S. Rollins, T. Ramahi, C. Mayer, T. Caulin–Glaser, E. Daher, M. Kosiborod, L. Bell, J. Setaro (2001)
Serum complement activation in congestive heart failure.American heart journal, 141 4
J. Damås, L. Gullestad, H. Aass, S. Simonsen, J. Fjeld, L. Wikeby, T. Ueland, H. Eiken, S. Frøland, P. Aukrust (2001)
Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure--modulatory effect of intravenous immunoglobulin.Journal of the American College of Cardiology, 38 1
V. Karantalis, J. Hare (2015)
Use of mesenchymal stem cells for therapy of cardiac disease.Circulation research, 116 8
Z. Kaya, Christoph Leib, Hugo Katus (2012)
Autoantibodies in heart failure and cardiac dysfunction.Circulation research, 110 1
A. Knowlton (2017)
Paying for the Tolls: The High Cost of the Innate Immune System for the Cardiac Myocyte.Advances in experimental medicine and biology, 1003
B. Levine, J. Kalman, L. Mayer, H. Fillit, M. Packer (1990)
Elevated circulating levels of tumor necrosis factor in severe chronic heart failure.The New England journal of medicine, 323 4
E. Birks, L. Felkin, N. Banner, A. Khaghani, P. Barton, M. Yacoub (2004)
Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 23 2
G. Torre-Amione, S. Kapadia, Joseph Lee, J. Durand, R. Bies, James Young, D. Mann (1996)
Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human HeartCirculation, 93
R. Altara, Z. Mallat, G. Booz, Fouad Zouein (2016)
The CXCL10/CXCR3 Axis and Cardiac Inflammation: Implications for Immunotherapy to Treat Infectious and Noninfectious Diseases of the HeartJournal of Immunology Research, 2016
A. Hasan, Lan Luo, Chen Yan, Tian-Xia Zhang, Y. Urata, S. Goto, S. Mangoura, M. Abdel-Raheem, Shouhua Zhang, Tao-Sheng Li (2016)
Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil RecruitmentPLoS ONE, 11
L. Gullestad, T. Ueland, J. Fjeld, E. Holt, T. Gundersen, K. Breivik, M. Følling, A. Hodt, R. Skårdal, J. Kjekshus, A. Andreassen, E. Kjekshus, R. Wergeland, A. Yndestad, S. Frøland, A. Semb, P. Aukrust (2005)
Effect of Thalidomide on Cardiac Remodeling in Chronic Heart Failure: Results of a Double-Blind, Placebo-Controlled StudyCirculation, 112
S. Levick, Giselle Meléndez, É. Plante, Jennifer Mclarty, G. Brower, J. Janicki (2011)
Cardiac mast cells: the centrepiece in adverse myocardial remodelling.Cardiovascular research, 89 1
S. Frantz, L. Kobzik, Young-Dae Kim, R. Fukazawa, R. Medzhitov, Richard Lee, Ralph Kelly (1999)
Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.The Journal of clinical investigation, 104 3
K. Youker, C. Assad-Kottner, A. Cordero‐Reyes, Alejandro Trevino, Jose Flores‐Arredondo, R. Barrios, E. Fernández-Sada, J. Estep, A. Bhimaraj, G. Torre-Amione (2014)
High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: humoral activation, a potential contributor of disease progression.European heart journal, 35 16
L. Timmers, J. Sluijter, J. Keulen, I. Hoefer, M. Nederhoff, M. Goumans, P. Doevendans, C. Echteld, J. Joles, P. Quax, J. Piek, G. Pasterkamp, D. Kleijn (2008)
Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial InfarctionCirculation Research, 102
S. Bansal, M. Ismahil, M. Goel, Bindiya Patel, T. Hamid, G. Rokosh, S. Prabhu (2017)
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart FailureCirculation: Heart Failure, 10
Vijaiganesh Nagarajan, Adrian Hernández, C. Cauthen, R. Starling, Wilson Tang (2017)
Usefulness of cell‐mediated immune function in risk stratification for patients with advanced heart failureAmerican Heart Journal, 183
J. Matsubara, S. Sugiyama, Toshimitsu Nozaki, E. Akiyama, Y. Matsuzawa, H. Kurokawa, Hirofumi Maeda, K. Fujisue, K. Sugamura, E. Yamamoto, K. Matsui, H. Jinnouchi, H. Ogawa (2014)
Incremental Prognostic Significance of the Elevated Levels of Pentraxin 3 in Patients With Heart Failure With Normal Left Ventricular Ejection FractionJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 3
Toshiyuki Takahashi (2008)
Toll-like receptors and myocardial contractile dysfunction.Cardiovascular research, 78 1
D. Mann, J. McMurray, M. Packer, K. Swedberg, J. Borer, W. Colucci, J. Djian, H. Drexler, A. Feldman, L. Køber, H. Krum, Peter Liu, M. Nieminen, L. Tavazzi, D. Veldhuisen, A. Waldenstrom, M. Warren, A. Westheim, F. Zannad, T. Fleming (2004)
Targeted Anticytokine Therapy in Patients With Chronic Heart Failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)Circulation: Journal of the American Heart Association, 109
M. Ohlow, M. Brunelli, M. Schreiber, B. Lauer (2017)
Therapeutic effect of immunoadsorption and subsequent immunoglobulin substitution in patients with dilated cardiomyopathy: Results from the observational prospective Bad Berka Registry.Journal of cardiology, 69 2
H. Sager, M. Hulsmans, K. Lavine, Marina Moreira, T. Heidt, G. Courties, Yuan Sun, Y. Iwamoto, Benoit Tricot, Omar Khan, J. Dahlman, A. Borodovsky, K. Fitzgerald, Daniel Anderson, R. Weissleder, P. Libby, F. Swirski, M. Nahrendorf (2016)
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.Circulation research, 119 7
Zhengfeng Zhu, T. Tang, Wen-Yong Dong, Yuanyuan Li, N. Xia, Wen-cai Zhang, Su-feng Zhou, Jing Yuan, Meng-yang Liao, Jing-jing Li, Jiao Jiao, Shaofang Nie, Qing Wang, X. Tu, Chengqi Xu, Y. Liao, G. Shi, Xiang Cheng (2015)
Defective circulating CD4+LAP+ regulatory T cells in patients with dilated cardiomyopathyJournal of Leukocyte Biology, 97
J. Damås, L. Gullestad, T. Ueland, N. Solum, S. Simonsen, S. Frøland, P. Aukrust (2000)
CXC-chemokines, a new group of cytokines in congestive heart failure--possible role of platelets and monocytes.Cardiovascular research, 45 2
M. Kallikourdis, E. Martini, P. Carullo, C. Sardi, G. Roselli, C. Greco, D. Vignali, Federica Riva, Anne Berre, T. Stølen, A. Fumero, G. Faggian, E. Pasquale, L. Elia, C. Rumio, D. Catalucci, R. Papait, G. Condorelli (2017)
T cell costimulation blockade blunts pressure overload-induced heart failureNature Communications, 8
Suresh Palaniyandi, Lihan Sun, Julio Ferreira, Daria Mochly-Rosen (2008)
Protein kinase C in heart failure: a therapeutic target?Cardiovascular Research, 82
Y. Sakata, Jian-wen Dong, Jesus Vallejo, Chien‐Hua Huang, J. Baker, Kevin Tracey, Osamu Tacheuchi, S. Akira, Douglas Mann (2007)
Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology, 292 1
M. Jung, Yonggang Ma, R. Iyer, K. DeLeon-Pennell, A. Yabluchanskiy, M. Garrett, M. Lindsey (2017)
IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activationBasic Research in Cardiology, 112
Yangchen Dhondup, I. Sjaastad, H. Scott, Ø. Sandanger, Lili Zhang, S. Haugstad, J. Aronsen, T. Ranheim, S. Holmen, K. Alfsnes, M. Ahmed, H. Attramadal, L. Gullestad, P. Aukrust, G. Christensen, A. Yndestad, L. Vinge (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO MicePLoS ONE, 10
G. Torre-Amione, F. Sestier, B. Radovančević, James Young (2004)
Effects of a novel immune modulation therapy in patients with advanced chronic heart failure: results of a randomized, controlled, phase II trial.Journal of the American College of Cardiology, 44 6
C. Defilippi, R. Christenson (2015)
Evolving role of galectin-3 as a cardiac biomarker: heart failure with preserved ejection fraction and renal function, important pieces of the puzzle.JACC. Heart failure, 3 3
Alexander Pinto, A. Ilinykh, Malina Ivey, J. Kuwabara, M. D’Antoni, R. Debuque, Anjana Chandran, Lina Wang, Komal Arora, N. Rosenthal, M. Tallquist (2016)
Revisiting Cardiac Cellular Composition.Circulation research, 118 3
R. Voll, M. Herrmann, Edith Roth, C. Stach, J. Kalden, I. Girkontaitė (1997)
Immunosuppressive effects of apoptotic cellsNature, 390
B. Bozkurt, G. Torre-Amione, M. Warren, James Whitmore, O. Soran, A. Feldman, D. Mann (2001)
Results of Targeted Anti–Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart FailureCirculation: Journal of the American Heart Association, 103
D. Mann (2015)
Innate immunity and the failing heart: the cytokine hypothesis revisited.Circulation research, 116 7
B. Dieplinger, T. Mueller (2015)
Soluble ST2 in heart failure.Clinica chimica acta; international journal of clinical chemistry, 443
D. Vredevoe, Mel Widawski, G. Fonarow, M. Hamilton, O. Martínez-Maza, J. Gage (2004)
Interleukin-6 (IL-6) expression and natural killer (NK) cell dysfunction and anergy in heart failure.The American journal of cardiology, 93 8
M. Nahrendorf, F. Swirski (2013)
Monocyte and Macrophage Heterogeneity in the HeartCirculation Research, 112
Anne Waehre, M. Vistnes, I. Sjaastad, S. Nygård, Cathrine Husberg, I. Lunde, P. Aukrust, A. Yndestad, L. Vinge, Dina Behmen, C. Neukamm, H. Brun, E. Thaulow, G. Christensen (2012)
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle.Journal of applied physiology, 112 8
AA Knowlton (2017)
The immunology of cardiovascular homeostasis and pathology
Haitao Guo, Justin Callaway, J. Ting (2015)
Inflammasomes: mechanism of action, role in disease, and therapeuticsNature Medicine, 21
J. Janicki, G. Brower, S. Levick (2015)
The emerging prominence of the cardiac mast cell as a potent mediator of adverse myocardial remodeling.Methods in molecular biology, 1220
Yonggang Ma, R. Chilton, M. Lindsey (2012)
Heart rate reduction: an old and novel candidate heart failure therapy.Hypertension, 59 5
E. Chung, M. Packer, K. Lo, A. Fasanmade, J. Willerson (2003)
Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-&agr;, in Patients With Moderate-to-Severe Heart Failure: Results of the Anti-TNF Therapy Against Congestive Heart failure (ATTACH) TrialCirculation: Journal of the American Heart Association, 107
O. Iborra-Egea, C. Gálvez-Montón, S. Roura, I. Perea-Gil, C. Prat-Vidal, C. Soler-Botija, A. Bayés‐Genís (2017)
Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approachNPJ Systems Biology and Applications, 3
A. Cordero‐Reyes, K. Youker, G. Torre-Amione (2014)
The role of B-cells in heart failure.Methodist DeBakey cardiovascular journal, 9 1
Yuji Nagatomo, D. McNamara, Jeffrey Alexis, Leslie Cooper, G. Dec, Daniel Pauly, R. Sheppard, Randall Starling, W.H. Tang, K. Janosko, Charles McTiernan, Barry London, K. Hanley-Yanez, J. Gorcsan, Hidekazu Tanaka, Mathew Suffoletto, Cynthia Oblak, A. McNallan, LuAnne Koenig, Paul Mather, Natalie Pierson, Sharon Rubin, Yanique Bell, Alicia Ervin, J. Boehmer, Patricia Frey, Jeffrey Alexis, J. Schrack, Pam LaDuke, G. Torre-Amione, Jeannie Arredondo, Pamela Smith, Stephanie Fuoco, I. Wittstein, Elayne Breton, V. Thohan, Deborah Wesley, D. Cocca-Spofford, David Markham, Lynn Fernandez, Colleen Debes, Mark Zucker, Laura Adams, Peter Liu, Judith Renton, Jagat Narula, Byron Allen, Elizabeth Westberg (2017)
Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against β1-Adrenergic Receptors.Journal of the American College of Cardiology, 69 8
H. Sager, Partha Dutta, J. Dahlman, M. Hulsmans, G. Courties, Yuan Sun, T. Heidt, Claudio Vinegoni, A. Borodovsky, K. Fitzgerald, G. Wojtkiewicz, Y. Iwamoto, Benoit Tricot, Omar Khan, Kevin Kauffman, Yiping Xing, Taylor Shaw, P. Libby, R. Langer, R. Weissleder, F. Swirski, Daniel Anderson, M. Nahrendorf (2016)
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarctionScience Translational Medicine, 8
(2008)
Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of Toll-like receptor 9
G. Torre-Amione, S. Anker, R. Bourge, W. Colucci, B. Greenberg, P. Hildebrandt, A. Keren, M. Motro, L. Moye, J. Otterstad, C. Pratt, P. Ponikowski, J. Rouleau, F. Sestier, B. Winkelmann, James Young (2008)
Results of a non-specific immunomodulation therapy in chronic heart failure (ACCLAIM trial): a placebo-controlled randomised trialThe Lancet, 371
T. Nevers, Ane Salvador, Anna Grodecki-Pena, A. Knapp, Francisco Velázquez, M. Aronovitz, N. Kapur, R. Karas, Robert Blanton, P. Alcaide (2015)
Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart FailureCirculation: Heart Failure, 8
V. Fadok, D. Bratton, A. Konowal, Peter Freed, J. Westcott, P. Henson (1998)
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.The Journal of clinical investigation, 101 4
Huan Wang, Lei Hou, Dongmin Kwak, J. Fassett, Xin Xu, A. Chen, W. Chen, B. Blazar, Yawei Xu, Jennifer Hall, Jun-bo Ge, R. Bache, Yingjie Chen (2016)
Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure ProgressionHypertension, 68
M. Dandel, G. Wallukat, Angela Englert, H. Lehmkuhl, C. Knosalla, R. Hetzer (2012)
Long‐term benefits of immunoadsorption in β1‐adrenoceptor autoantibody‐positive transplant candidates with dilated cardiomyopathyEuropean Journal of Heart Failure, 14
A. Val-Blasco, M. Piedras, G. Ruiz‐Hurtado, Natalia Suárez, P. Prieto, S. González-Ramos, N. Gómez-Hurtado, C. Delgado, L. Pereira, G. Benito, C. Zaragoza, N. Domenech, M. Crespo-Leiro, D. Vasquez-Echeverri, G. Núñez, E. López-Collazo, L. Boscá, M. Fernández-Velasco (2017)
Role of NOD1 in Heart Failure Progression via Regulation of Ca2+ Handling.Journal of the American College of Cardiology, 69 4
T. Yoshikawa, A. Baba, M. Akaishi, Y. Wakabayashi, T. Monkawa, M. Kitakaze, T. Izumi, H. Tomoike (2016)
Immunoadsorption therapy for dilated cardiomyopathy using tryptophan column—A prospective, multicenter, randomized, within‐patient and parallel‐group comparative study to evaluate efficacy and safetyJournal of Clinical Apheresis, 31
S. Frantz, M. Nahrendorf (2014)
Cardiac macrophages and their role in ischaemic heart disease.Cardiovascular research, 102 2
Naoko Okamoto, T. Noma, Y. Ishihara, Y. Miyauchi, W. Takabatake, S. Oomizu, G. Yamaoka, Makoto Ishizawa, Tsunetatsu Namba, K. Murakami, Y. Iwado, K. Ohmori, M. Kohno (2014)
Prognostic value of circulating regulatory T cells for worsening heart failure in heart failure patients with reduced ejection fraction.International heart journal, 55 3
K. Murphy, J. Rosenthal (2017)
Progress in the Presence of Failure: Updates in Chronic Systolic Heart Failure ManagementCurrent Treatment Options in Cardiovascular Medicine, 19
H. Sager, T. Kessler, H. Schunkert (2017)
Monocytes and macrophages in cardiac injury and repair.Journal of thoracic disease, 9 Suppl 1
Jianping Li, S. Jubair, S. Levick, J. Janicki (2016)
THE AUTOCRINE ROLE OF TRYPTASE IN PRESSURE OVERLOAD-INDUCED MAST CELL ACTIVATION, CHYMASE RELEASE AND CARDIAC FIBROSIS.IJC metabolic & endocrine, 10
Lei Wang, Yulin Li, Congcong Zhang, W. Cui, Xia Wang, Yong Xia, Jie Du, Hui-Hua Li (2014)
Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation.Cardiovascular research, 101 3
N. Naftali-Shani, L. Levin-Kotler, Dahlia Palevski, U. Amit, David Kain, N. Landa, E. Hochhauser, J. Leor (2017)
Left Ventricular Dysfunction Switches Mesenchymal Stromal Cells Toward an Inflammatory Phenotype and Impairs Their Reparative Properties Via Toll-Like Receptor-4Circulation, 135
J. Müller, G. Wallukat, M. Dandel, H. Bieda, K. Brandes, S. Spiegelsberger, E. Nissen, R. Kunze, R. Hetzer (2000)
Immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy.Circulation, 101 4
E. Birks (2013)
Molecular changes after left ventricular assist device support for heart failure.Circulation research, 113 6
Yusuke Sugi, H. Yasukawa, H. Kai, D. Fukui, Nobuyoshi Futamata, K. Mawatari, T. Oba, N. Nagata, Sachiko Kyougoku, M. Koga, T. Imaizumi (2011)
Reduction and activation of circulating dendritic cells in patients with decompensated heart failure.International journal of cardiology, 147 2
B. Tassell, J. Raleigh, A. Abbate (2015)
Targeting Interleukin-1 in Heart Failure and Inflammatory Heart DiseaseCurrent Heart Failure Reports, 12
I. Tracchi, G. Ghigliotti, Marzia Mura, S. Garibaldi, P. Spallarossa, C. Barisione, V. Boasi, M. Brunelli, L. Corsiglia, A. Barsotti, C. Brunelli (2009)
Increased neutrophil lifespan in patients with congestive heart failureEuropean Journal of Heart Failure, 11
Fanny Laroumanie, V. Douin-Echinard, J. Pozzo, O. Lairez, F. Tortosa, Claire Vinel, Christine Delage, D. Calise, M. Dutaur, A. Parini, N. Pizzinat (2014)
CD4+ T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure OverloadCirculation, 129
T. Shishido, N. Nozaki, S. Yamaguchi, Y. Shibata, J. Nitobe, T. Miyamoto, Hiroki Takahashi, T. Arimoto, K. Maeda, M. Yamakawa, O. Takeuchi, S. Akira, Y. Takeishi, I. Kubota (2002)
Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial InfarctionCirculation: Journal of the American Heart Association, 108
G. Arutyunov, O. Kostyukevich, R. Serov, N. Rylova, N. Bylova (2008)
Collagen accumulation and dysfunctional mucosal barrier of the small intestine in patients with chronic heart failure.International journal of cardiology, 125 2
Purpose of review Immune system activation plays a central role in heart failure progres- sion. Large-scale immune modulatory clinical trials targeting tumor necrosis factor-α and broad spectrum immune modulation have been negative. The objective of this review is to highlight past, present, and what is in the horizon for the immunomodulation in heart failure with a focus of biologics. Recent findings Strategies targeting interleukin-1 pathway are currently undergoing clinical evaluation and data from pilot studies are promising. The potential of cell therapy for immune modulation is increasingly recognized in clinical trials. Strategies targeting anti-cardiac antibodies such as immunoadsorption and intra- venous immunoglobulin have been used in clinical practice with positive out- comes but large pragmatic clinical trials are lacking. The use of an aptamer to block anti-cardiac antibodies is undergoing phase 1 clinical evaluation. Promising targets include inflammasomes, toll-like receptors, chemokines, natural killer cells, and macrophages. Summary Large-scale immune modulatory clinical trials have been negative. Nev- ertheless, the experience gained from them along with increasing understanding of molecular mechanisms of immune pathophysiology in heart failure is leading to rapid recognition of new therapeutic targets and approaches. 26 Page 2 of 13 Curr Treat Options Cardio Med (2018) 20: 26
Current Treatment Options in Cardiovascular Medicine – Springer Journals
Published: Mar 15, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.