Immune globulin

Immune globulin Reactions 1680, p168 - 2 Dec 2017 Headache and gastrointestinal symptoms: case report An adult woman [age at reaction onset not clearly stated] developed headache and gastrointestinal symptoms during therapy with immune globulin [IVIg; route and dosage not stated]. The woman, at the age of 46 years, was diagnosed with generalised myasthenia gravis. She received pyridostigmine and prednisolone therapy. However, there was no improvement. Then, she had undergone thymectomy and plasma exchange. Following the thymectomy, her generalised weakness and bulbar symptoms were exacerbated. Hence, she was administered with immune globulin, followed by plasma exchange therapy. Her symptoms then improved. However, after 3–4 months, her generalised weakness worsened again. She was then prescribed with plasma exchange and 3–4 courses of immune globulin for every year. However, due to the immune globulin therapy, she developed headache and gastrointestinal symptoms [time to reactions onsets and outcomes not stated]. Author comment: "She was prescribed [plasma exchange] and 3–4 courses of [immune globulin] every year, but was unable to tolerate the medication because of headache or gastrointestinal symptoms." Muto K, et al. Memory B cell resurgence requires repeated rituximab in myasthenia gravis. Neuromuscular Disorders 27: 918-922, No. 10, Oct 2017. Available from: URL: http://doi.org/10.1016/j.nmd.2017.06.012 - Japan 803284364 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Immune globulin

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39099-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p168 - 2 Dec 2017 Headache and gastrointestinal symptoms: case report An adult woman [age at reaction onset not clearly stated] developed headache and gastrointestinal symptoms during therapy with immune globulin [IVIg; route and dosage not stated]. The woman, at the age of 46 years, was diagnosed with generalised myasthenia gravis. She received pyridostigmine and prednisolone therapy. However, there was no improvement. Then, she had undergone thymectomy and plasma exchange. Following the thymectomy, her generalised weakness and bulbar symptoms were exacerbated. Hence, she was administered with immune globulin, followed by plasma exchange therapy. Her symptoms then improved. However, after 3–4 months, her generalised weakness worsened again. She was then prescribed with plasma exchange and 3–4 courses of immune globulin for every year. However, due to the immune globulin therapy, she developed headache and gastrointestinal symptoms [time to reactions onsets and outcomes not stated]. Author comment: "She was prescribed [plasma exchange] and 3–4 courses of [immune globulin] every year, but was unable to tolerate the medication because of headache or gastrointestinal symptoms." Muto K, et al. Memory B cell resurgence requires repeated rituximab in myasthenia gravis. Neuromuscular Disorders 27: 918-922, No. 10, Oct 2017. Available from: URL: http://doi.org/10.1016/j.nmd.2017.06.012 - Japan 803284364 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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