Immune globulin

Immune globulin Reactions 1680, p169 - 2 Dec 2017 Supraventricular tachycardia: 2 case reports A neonate girl and a neonate boy [ages at the time of reactions onsets not stated] were described, who developed supraventricular tachycardia (SVT) following administration of immune globulin [dosages not stated]. Case 1: A baby girl was born at 36 weeks of gestation by spontaneous vaginal delivery to a 30-year-old woman. At the th 6 postnatal hour, the baby girl’s bilirubin level was 2.8 mg/dL corresponding to a pathologic rate of increase. She was known to develop an immune haemolysis due to ABO incompatibility and was administered IV infusion of immune globulin to be given over 4 hours. After 75 mins of the immune globulin administration, her HR suddenly increased to 260 beats/min. The electrocardiography revealed narrow QRS SVT. She was treated with adenosine and her HR returned to normal (144/min). Case 2: A baby boy was born at 38 weeks of gestation to a 29-year-old healthy woman. After birth, his umbilical cord bilirubin level increased, corresponding to a pathologic rate of increase. Subsequently, he started receiving IV infusion of immune globulin to be given over 4 hours. Two hours later, his HR suddenly increased to 230 beats/min. The ECG revealed narrow QRS SVT. He was treated with adenosine and his HR returned to normal. However, the SVT episodes recurrent on th th the 5 and 8 days of life, which responded to adenosine th treatment. On the 9 day of his life, the SVT episode did not show response to the adenosine treatment, but responded to digoxin and amiodarone therapy. Author comment: "Cardiorespiratory monitoring during IVIG infusion can be recommended because of the possibility of this potentially lifethreatening adverse effect [of supraventricular tachycardia]." Tufekci S, et al. Cardiac rhythm abnormalities during intravenous immunoglobulin G(IVIG) infusion in two newborn infants: coincidence or association? Clinical Case Reports 3: 731-734, No. 9, Sep 2015. Available from: URL: http:// - Turkey 803283900 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals

Immune globulin

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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