Imiquimod

Imiquimod Reactions 1704, p193 - 2 Jun 2018 Cutaneous metastatic melanoma: case report A 67-year-old man developed cutaneous metastatic melanoma following treatment with imiquimod [dosage, time to reaction onset and outcome not stated]. The man presented with a two months history of multiple cutaneous deposits, which appeared shortly following application of imiquimod for presumed actinic keratoses to the forearms. Examination revealed a widespread eruption of dark brown, purpuric papules scattered over the trunk, face and lower limbs. Later, he was diagnosed with metastatic melanoma with a positive BRAF V600E mutation. Positron emission tomography scan revealed no definitive visceral metastasis or primary cutaneous melanoma. Author comment: "Paradoxically, there are emerging case reports of the development of keratoacanthomas and infiltrating squamous cell carcinoma at sites of previous imiquimod application." "To our knowledge, this is the first reported case of de novo cutaneous melanoma metastases following imiquimod application." Schauer A, et al. Fighting fire with fire: Cutaneous melanoma metastases following imiquimod use. Australasian Journal of Dermatology 59 (Suppl. 1): 103, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Australia 803323573 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Imiquimod

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46836-5
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p193 - 2 Jun 2018 Cutaneous metastatic melanoma: case report A 67-year-old man developed cutaneous metastatic melanoma following treatment with imiquimod [dosage, time to reaction onset and outcome not stated]. The man presented with a two months history of multiple cutaneous deposits, which appeared shortly following application of imiquimod for presumed actinic keratoses to the forearms. Examination revealed a widespread eruption of dark brown, purpuric papules scattered over the trunk, face and lower limbs. Later, he was diagnosed with metastatic melanoma with a positive BRAF V600E mutation. Positron emission tomography scan revealed no definitive visceral metastasis or primary cutaneous melanoma. Author comment: "Paradoxically, there are emerging case reports of the development of keratoacanthomas and infiltrating squamous cell carcinoma at sites of previous imiquimod application." "To our knowledge, this is the first reported case of de novo cutaneous melanoma metastases following imiquimod application." Schauer A, et al. Fighting fire with fire: Cutaneous melanoma metastases following imiquimod use. Australasian Journal of Dermatology 59 (Suppl. 1): 103, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Australia 803323573 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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