Imiquimod Reactions 1680, p166 - 2 Dec 2017 Crusting and discomfort: case report A 51-year-old man experienced crusting and discomfort during treatment with imiquimod [duration of treatment to reaction onset and outcome not stated]. The man presented with intense pruritic lesions on the penis, pubis, scrotum and gluteal region from three years. His history was significant for basal cell carcinoma on the bridge of the nose (treated with surgery), seborrhoeic dermatitis, idiopathic erythema nodosum and facial herpes simplex. Bases on his symptoms inverse psoriasis was suspected. Subsequently, he received acitretin and betamethasone, but no improvement was noted. Thereafter, investigations led to the diagnosis of extensive multifocal genital and perineal squamous cell carcinoma in-situ (SCCIS). Consequently, his treatment was started with 5% topical imiquimod cream five times a week. However, after three months of therapy, little improvement was noted. Additionally, he was unable to tolerate a longer course due to crusting and discomfort, even with rotation of application sites. The man’s imiquimod therapy was switched to fluorouracil [5-fluorouracil]. Author comment: "The patient was treated with imiquimod cream 5% five times per week. Little improvement occurred after 3 months of therapy. A longer course, even with application site rotation, could not be tolerated because of crusting and discomfort." Worley B, et al. p16+ Squamous cell carcinoma in situ masquerading as genital psoriasis. JAAD Case Reports 3: 542-545, No. 6, Nov 2017. Available from: URL: - Canada 803284561 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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