EDITORIAL Imaging the heart’s brain: Simultaneous innervation/perfusion analysis in the era of new CZT cameras a b Riccardo Liga, MD, and Alessia Gimelli, MD Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy Fondazione Toscana Gabriele Monasterio, Pisa, Italy Received May 4, 2016; accepted May 4, 2016 doi:10.1007/s12350-016-0541-0 5,9 tone, it has never gained a wide clinical acceptance. In See related article, pp. 1361–1369 fact, the heart-to-mediastinum (H/M) ratio and the 123 123 washout rate of I-metaiodobenzylguanidine ( I- MIBG), as easily quantiﬁed through planar scintigraphy, The entire heart is surrounded and penetrated by a have long represented the backbone of the radionuclide dense mesh of autonomic nervous terminals that con- evaluation of myocardial adrenergic activity. How- 1-3 stantly modulate its activity. Speciﬁcally, the ever, despite solid prognostic evidence in favor of their autonomic nervous system includes both a parasympa- implementation in daily clinical routine, planar mea- thetic and a sympathetic branch, which are equally sures of cardiac SNS function have remained somehow important and have specular effects on cardiac function. neglected, possibly due to the intrinsic rudimentariness As a general rule, the activation of the adrenergic system of the technique and to the ability to provide only
Journal of Nuclear Cardiology – Springer Journals
Published: May 18, 2016
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