Cardiovasc Intervent Radiol (2017) 40:1392–1400 DOI 10.1007/s00270-017-1651-z CLINICAL INVESTIGATION INTERVENTIONAL ONCOLOGY Image-Guided Transarterial Chemoembolization With Drug-Eluting Beads Loaded with Doxorubicin (DEBDOX) for Unresectable Hepatic Metastases from Melanoma: Technique and Outcomes 1 2 3 4 4 • • • • • Jack Rostas Alda Tam Takami Sato Larry Kelly Cliff Tatum 1 1 1 • • Charles Scoggins Kelly McMasters Robert C. G. Martin II Received: 15 December 2016 / Accepted: 4 April 2017 / Published online: 15 May 2017 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2017 Abstract Results Twenty patients received a total of 61 DEBDOX Purpose Hepatic metastasis from melanoma represents a treatments from January 2010 to March 2013. The median therapeutic dilemma, with limited effective options for the hepatic tumor burden was 40% (range 20–55), 18 patients 85% of cases deemed unresectable. Systemic agents confer (90%) had bilobar disease, and 13 patients (65%) had toxicity and, along with traditional local hepatic arterial- concomitant extrahepatic disease. At median assessment of directed therapies such as transarterial chemoembolization, 2.5 months, 11 patients (55%) exhibited a tumor response have not led to a signiﬁcant increase in survival. The aim of and 16
CardioVascular and Interventional Radiology – Springer Journals
Published: May 15, 2017
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