Ileal tract and Peyer’s patch innervation in scrapie-free versus scrapie-affected ovines

Ileal tract and Peyer’s patch innervation in scrapie-free versus scrapie-affected ovines Ileal Peyer’s patches (PPs) are involved early during sheep scrapie infection. This study qualitatively and semi-quantitatively evaluated ileal tract and PP innervation in 29 Sarda ovines of different age, PrP genotype and scrapie status. A prominent network of fibres was detected within PPs, mainly located in interfollicular lymphoid and stromal components. Intrafollicular fibres were rarely observed, with no apparent differences between scrapie-free and scrapie-affected animals, or among ovines carrying different PrP genotypes. In adult sheep, independent of their scrapie status, nerve fibres could be detected infrequently, close to the follicle-associated epithelium. Fibres were also detected within newly formed follicles and intrafollicular microgranulomas. Archives of Virology Springer Journals

Ileal tract and Peyer’s patch innervation in scrapie-free versus scrapie-affected ovines

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Springer Vienna
Copyright © 2009 by Springer-Verlag
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
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