Cardiovasc Drugs Ther (2017) 31:281–293 DOI 10.1007/s10557-017-6726-1 ORIGINAL ARTICLE Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial Differential Response in Acute Heart Failure 1 1 2 Licette C. Y. Liu & Mattia A. E. Valente & Douwe Postmus & 3 4 5 Christopher M. O’Connor & Marco Metra & Howard C. Dittrich & 6 7 8 8 Piotr Ponikowski & John R. Teerlink & Gad Cotter & Beth Davison & 9 10 11 John G. F. Cleland & Michael M. Givertz & Daniel M. Bloomfield & 1 1,2 1 Dirk J. van Veldhuisen & Hans L. Hillege & Peter van der Meer & Adriaan A. Voors Published online: 27 June 2017 The Author(s) 2017. This article is an open access publication Abstract and rolofylline. The biomarker-based sum score model includ- Background Over the last 50 years, clinical trials of novel inter- ed TNF-R1α, ST2, WAP four-disulfide core domain protein ventions for acute heart failure (AHF) have, with few exceptions, HE4 (WAP-4C), and total cholesterol, and the score ranged been neutral or shown harm. We hypothesize that this might be between 0 and 4. In patients with score 4
Cardiovascular Drugs and Therapy – Springer Journals
Published: Jun 27, 2017
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