Eur J Nutr (2018) 57:297–308 https://doi.org/10.1007/s00394-016-1319-5 ORIGINAL CONTRIBUTION Identification of urinary metabolites with potential blood pressure‑lowering effects in lentil‑fed spontaneously hypertensive rats 1,3 1,2,3 1,2,3 2,3 Matthew Hanson · Peter Zahradka · Carla G. Taylor · Michel Aliani Received: 13 June 2016 / Accepted: 29 September 2016 / Published online: 21 October 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract urine of SHR fed other pulses. Of these metabolites, only Purpose Urine samples were obtained from a previously citrulline is linked to blood pressure regulation via produc- completed study that showed lentil consumption attenu- tion of the vasodilator nitric oxide (NO). Several arginine- ates the increase in blood pressure that occurs over time in related compounds that are NO synthase substrates or spontaneously hypertensive rats (SHRs). The objective of inhibitors were detected in lentils but not the control diet or the present study was to compare the metabolite profile of other pulse powders. the urine samples from control and lentil-fed SHR in rela- Conclusions Consumption of lentils increases the availa- tion to the compounds present in lentils but not in other bility of arginine and several related compounds that could pulses. potentially elevate production of NO and contribute to the
European Journal of Nutrition – Springer Journals
Published: Oct 21, 2016
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