Mammalian Genome 11, 1145–1146 (2000). DOI: 10.1007/s003350010215 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Identification of the human switch alpha 2 region from a low-grade malt lymphoma Elena Nardini, Simona Rizzi, Sylvie Menard, Andrea Balsari Molecular Targeting Unit, Department of Experimental Oncology, National Cancer Institute, Via Venezian 1 Milan, and Institute of Pathology, University of Milan, 20133 Milan, Italy Received: 16 June 2000 / Accepted: 3 August 2000 Mucosa-Associated Lymphoid Tissue (MALT) lymphomas derive + − − − from marginal zone B-cells (typically IgM IgD ,CD5 ,CD10 ) and develop in a variety of extranodal locations, but most com- monly within the gastrointestinal tract (Harris et al. 1994; Woth- erspoon 1998). MALT lymphomas can be classified as either low or high grade and, in most cases, produce an immunoglobulin (Ig) with “M”-isotype. To obtain information on the maturational state of MALT lymphomas, we are investigating low-grade and high- Fig. 1. Southern blot analysis of grade cases for the presence of genomic rearrangements involving immunoglobulin heavy chain switch regions in one patient with low-grade the immunoglobulin heavy and chain (IgH) switch regions on Chr mucosa-associated lymphoid tissue 14q32 (Nardini et al. 2000, in preparation). lymphoma. Genomic DNA was
Mammalian Genome – Springer Journals
Published: Dec 1, 2000
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