Identification of palmatine as an inhibitor of West Nile virus

Identification of palmatine as an inhibitor of West Nile virus In this study, we investigated the specific inhibition of West Nile virus (WNV) NS2B-NS3 protease and viral propagation by palmatine, a chemical compound from Coptis chinensis Franch . It was demonstrated that palmatine could inhibit WNV NS2B-NS3 protease activity in an uncompetitive manner, with a 50% inhibitory concentration (IC 50 ) of 96 μM. Palmatine suppressed WNV without detectable cytotoxicity (a 50% effective concentration (EC 50 ) of 3.6 μM and a 50% cytotoxicity concentration (CC 50 ) of 1,031 μM). Furthermore, palmatine could also suppress dengue virus and yellow fever virus in a dose-dependent manner. This compound could potentially be developed for the treatment of flavivirus infections. Archives of Virology Springer Journals

Identification of palmatine as an inhibitor of West Nile virus

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Springer Vienna
Copyright © 2010 by Springer-Verlag
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
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