In this study, we investigated the specific inhibition of West Nile virus (WNV) NS2B-NS3 protease and viral propagation by palmatine, a chemical compound from Coptis chinensis Franch . It was demonstrated that palmatine could inhibit WNV NS2B-NS3 protease activity in an uncompetitive manner, with a 50% inhibitory concentration (IC 50 ) of 96 μM. Palmatine suppressed WNV without detectable cytotoxicity (a 50% effective concentration (EC 50 ) of 3.6 μM and a 50% cytotoxicity concentration (CC 50 ) of 1,031 μM). Furthermore, palmatine could also suppress dengue virus and yellow fever virus in a dose-dependent manner. This compound could potentially be developed for the treatment of flavivirus infections.
Archives of Virology – Springer Journals
Published: Aug 1, 2010
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